2RDA

Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Thymidylate synthase	polymer	313	35734.9	6	UniProt (P04818) Pfam (PF00303)	Homo sapiens (Human)	TS, TSase
2	G, H, J, K, L (A, C, D, E)	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)
3	I, M (C, E)	BETA-MERCAPTOETHANOL	non-polymer		78.1	2	Chemie (BME)
4	N, O, P, Q, R... (A, B, C, D, E...)	water	water		18.0	182	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 313 (UniProt: P04818)

PDB	External Database	Details
Lys 163	Arg 163	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	214409.6
Non-Polymers*	Number of molecules	7
	Total formula weight	631.1
All*	Total formula weight	215040.7

*Water molecules are not included.