1HW3

STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS

Summary for 1HW3

Entry DOI	10.2210/pdb1hw3/pdb
Related	1HW4
Descriptor	THYMIDYLATE SYNTHASE, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	thymidylate synthase, methyltransferase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36513.72
Authors	Phan, J.,Steadman, J.D.,Koli, S.,Ding, W.C.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. (deposition date: 2001-01-09, release date: 2001-01-24, Last modification date: 2022-04-13)
Primary citation	Phan, J.,Steadman, D.J.,Koli, S.,Ding, W.C.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. J.Biol.Chem., 276:14170-14177, 2001 Cited by PubMed: 11278511 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation