1HW3
STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | THYMIDYLATE SYNTHASE | polymer | 313 | 36067.4 | 1 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (human) | TS |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Cme 43 | Cys 42 | modified residue |
| Cme 180 | Cys 179 | modified residue |
| Cme 195 | Cys 194 | modified residue |
| Cme 199 | Cys 198 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36067.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 446.3 | |
| All* | Total formula weight | 36513.7 |
