3EHI
Crystal Structure of Human Thymidyalte Synthase M190K with Loop 181-197 stabilized in the inactive conformation
Summary for 3EHI
Entry DOI | 10.2210/pdb3ehi/pdb |
Related | 1HVY 1HW3 1YPV 2ONB 2RD8 2RDA 3EGY |
Descriptor | Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | methyltransferase, nucleotide biosynthesis, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P04818 |
Total number of polymer chains | 1 |
Total formula weight | 36167.35 |
Authors | Lovelace, L.L.,Gibson, L.M.,Johnson, S.R.,Berger, S.H.,Lebioda, L. (deposition date: 2008-09-12, release date: 2009-08-18, Last modification date: 2023-08-30) |
Primary citation | Lovelace, L.L.,Johnson, S.R.,Gibson, L.M.,Bell, B.J.,Berger, S.H.,Lebioda, L. Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation. Protein Sci., 18:1628-1636, 2009 Cited by PubMed: 19569192DOI: 10.1002/pro.171 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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