3EHI
Crystal Structure of Human Thymidyalte Synthase M190K with Loop 181-197 stabilized in the inactive conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Thymidylate synthase | polymer | 313 | 35913.2 | 1 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (human) | TSase, TS |
| 2 | B, C (X) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (X) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | E (X) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
X: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Lys 190 | Met 190 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35913.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 254.2 | |
| All* | Total formula weight | 36167.4 |
