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3JCA
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BU of 3jca by Molmil
Core model of the Mouse Mammary Tumor Virus intasome
Descriptor: 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ...
Authors:Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N.
Deposit date:2015-11-24
Release date:2016-02-17
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5DS5
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BU of 5ds5 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA and Mg
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
Deposit date:2015-09-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.951 Å)
Cite:Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
5DS4
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BU of 5ds4 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER)
Authors:Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
Deposit date:2015-09-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
5DS6
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BU of 5ds6 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
Deposit date:2015-09-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.352 Å)
Cite:Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
5M0R
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BU of 5m0r by Molmil
Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex
Descriptor: integrase, tDNA, vDNA, ...
Authors:Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P.
Deposit date:2016-10-05
Release date:2017-01-18
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
7Z1Z
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BU of 7z1z by Molmil
MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution
Descriptor: DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ...
Authors:Pye, V.E, Ballandras-Colas, A, Cherepanov, P.
Deposit date:2022-02-25
Release date:2022-05-11
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
7JN3
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BU of 7jn3 by Molmil
Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048
Descriptor: (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ...
Authors:Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P.
Deposit date:2020-08-03
Release date:2021-03-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
Commun Biol, 4, 2021
9C9M
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BU of 9c9m by Molmil
HIV-1 intasome core bound with DTG
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ...
Authors:Li, M, Craigie, R.
Deposit date:2024-06-14
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (2.01 Å)
Cite:HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration.
Viruses, 16, 2024
5D7U
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BU of 5d7u by Molmil
Crystal structure of the C-terminal domain of MMTV integrase
Descriptor: ISOPROPYL ALCOHOL, Pr160
Authors:Cook, N.J, Pye, V.E, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-08-14
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5CZ1
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BU of 5cz1 by Molmil
Crystal structure of the catalytic core domain of MMTV integrase
Descriptor: integrase
Authors:Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-07-31
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5CZ2
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BU of 5cz2 by Molmil
Crystal structure of a two-domain fragment of MMTV integrase
Descriptor: MAGNESIUM ION, Pol polyprotein, ZINC ION
Authors:Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-07-31
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
6VWS
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BU of 6vws by Molmil
Hexamer of Helical HIV capsid by RASTR method
Descriptor: HIV capsid protein
Authors:Zhao, H, Iqbal, N, Asturias, F, Kvaratskhelia, M, Vanblerkom, P.
Deposit date:2020-02-20
Release date:2020-10-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.08 Å)
Cite:Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
Science, 370, 2020
6NUJ
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BU of 6nuj by Molmil
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor BI-224436
Descriptor: (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, Integrase
Authors:Lindenberger, J.J, Kvaratskhelia, M.
Deposit date:2019-02-01
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.100027 Å)
Cite:HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
Elife, 8, 2019
5MLU
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BU of 5mlu by Molmil
Crystal structure of the PFV GAG CBS bound to a mononucleosome
Descriptor: DNA (145-MER), Histone H2A type 1, Histone H2B, ...
Authors:Pye, V.E, Maskell, D.P, Lesbats, P, Cherepanov, P.
Deposit date:2016-12-07
Release date:2017-05-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for spumavirus GAG tethering to chromatin.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6GX9
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BU of 6gx9 by Molmil
Crystal structure of the TNPO3 - CPSF6 RSLD complex
Descriptor: BENZAMIDINE, BICINE, Cleavage and polyadenylation specificity factor subunit 6, ...
Authors:Cherepanov, P, Cook, N.
Deposit date:2018-06-26
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Nucleic Acids Res., 47, 2019
7ZPP
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BU of 7zpp by Molmil
Cryo-EM structure of the MVV CSC intasome at 4.5A resolution
Descriptor: Integrase, vDNA, non-transferred strand, ...
Authors:Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P.
Deposit date:2022-04-28
Release date:2022-05-11
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration
Science, 355, 2017
8A1P
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BU of 8a1p by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P.
Deposit date:2022-06-01
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Mbio, 14, 2023
8A1Q
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BU of 8a1q by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor STP0404 (Pirmitegravir)
Descriptor: (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, 1,2-ETHANEDIOL, Integrase, ...
Authors:Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P.
Deposit date:2022-06-01
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Mbio, 14, 2023
5T3A
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BU of 5t3a by Molmil
Maedi-Visna virus (MVV) integrase CCD-CTD (residues 60-275)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, integrase
Authors:Cook, N.J, Pye, V.E, Cherepanov, P.
Deposit date:2016-08-25
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
5UOT
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BU of 5uot by Molmil
CryoEM structure of the helical assembly of full length MxB
Descriptor: Interferon-induced GTP-binding protein Mx2
Authors:Perilla, J.R, Alvarez, F.J.D, Zhang, P, Schulten, K.
Deposit date:2017-02-01
Release date:2018-02-21
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.
Sci Adv, 3, 2017
7SNQ
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BU of 7snq by Molmil
Hexamer HIV-1 CA in complex with CPSF6 peptide and IP6 ligand
Descriptor: CHLORIDE ION, Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6, ...
Authors:Bester, S.M, Kvaratskhelia, M.
Deposit date:2021-10-28
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
Nat Commun, 13, 2022
7UT1
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BU of 7ut1 by Molmil
Higher-order assembly of multiple MMTV strand transfer complex intasomes
Descriptor: Integrase, ZINC ION, tDNA strand, ...
Authors:Jozwik, I, Lyumkis, D.
Deposit date:2022-04-26
Release date:2022-08-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:B-to-A transition in target DNA during retroviral integration.
Nucleic Acids Res., 50, 2022
7USF
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BU of 7usf by Molmil
Mouse mammary tumor virus strand transfer complex intasome
Descriptor: CALCIUM ION, Integrase, ZINC ION, ...
Authors:Jozwik, I, Lyumkis, D.
Deposit date:2022-04-25
Release date:2022-08-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:B-to-A transition in target DNA during retroviral integration.
Nucleic Acids Res., 50, 2022
7U32
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BU of 7u32 by Molmil
MVV cleaved synaptic complex (CSC) intasome at 3.4 A resolution
Descriptor: CALCIUM ION, DNA EV272, DNA EV273, ...
Authors:Shan, Z, Pye, V.E, Cherepanov, P, Lyumkis, D.
Deposit date:2022-02-25
Release date:2022-05-11
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
5KRS
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BU of 5krs by Molmil
HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid
Descriptor: 3-pyrrol-1-ylthiophene-2-carboxylic acid, DIMETHYL SULFOXIDE, Integrase
Authors:Patel, D, Bauman, J.D, Arnold, E.
Deposit date:2016-07-07
Release date:2016-09-28
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
J.Biol.Chem., 291, 2016

 

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