6NUJ

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor BI-224436

Summary for 6NUJ

Entry DOI	10.2210/pdb6nuj/pdb
Descriptor	Integrase, (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid (3 entities in total)
Functional Keywords	hiv, integrase, inhibitor, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	18886.19
Authors	Lindenberger, J.J.,Kvaratskhelia, M. (deposition date: 2019-02-01, release date: 2019-12-11, Last modification date: 2023-10-11)
Primary citation	Koneru, P.C.,Francis, A.C.,Deng, N.,Rebensburg, S.V.,Hoyte, A.C.,Lindenberger, J.,Adu-Ampratwum, D.,Larue, R.C.,Wempe, M.F.,Engelman, A.N.,Lyumkis, D.,Fuchs, J.R.,Levy, R.M.,Melikyan, G.B.,Kvaratskhelia, M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife, 8:-, 2019 Cited by PubMed: 31120420 DOI: 10.7554/eLife.46344 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.10002700303 Å)

Structure validation