6NUJ
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor BI-224436
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrase | polymer | 166 | 18443.7 | 1 | UniProt (F2WR52) | Human immunodeficiency virus 1 | |
| 2 | B (A) | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid | non-polymer | 442.5 | 1 | Chemie (L3D) | |||
| 3 | C (A) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: F2WR52)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| His 49 | - | expression tag |
| His 185 | Phe 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18443.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 442.5 | |
| All* | Total formula weight | 18886.2 |
