7Z1Z

MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution

Summary for 7Z1Z

• Entry DOI: 10.2210/pdb7z1z/pdb
• EMDB information: 14453
• Descriptor: Pol polyprotein, PC4 and SFRS1-interacting protein, DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), ... (6 entities in total)
• Functional Keywords: intasome, integrase, mvv, lentivirus, hiv, strand transfer complex, ledgf, ibd, dna, integration, viral protein
• Biological source: Visna/maedi virus EV1 KV1772; More
• Total number of polymer chains: 24
• Total formula weight: 599890.05

Authors

Pye, V.E.,Ballandras-Colas, A.,Cherepanov, P. (deposition date: 2022-02-25, release date: 2022-05-11, Last modification date: 2022-12-21)

• Primary citation: Ballandras-Colas, A.,Chivukula, V.,Gruszka, D.T.,Shan, Z.,Singh, P.K.,Pye, V.E.,McLean, R.K.,Bedwell, G.J.,Li, W.,Nans, A.,Cook, N.J.,Fadel, H.J.,Poeschla, E.M.,Griffiths, D.J.,Vargas, J.,Taylor, I.A.,Lyumkis, D.,Yardimci, H.,Engelman, A.N.,Cherepanov, P.; Multivalent interactions essential for lentiviral integrase function.; Nat Commun, 13:2416-, 2022; DOI: 10.1038/s41467-022-29928-8

Experimental method

ELECTRON MICROSCOPY (3.5 Å)