8A1P
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D
Summary for 8A1P
Entry DOI | 10.2210/pdb8a1p/pdb |
Descriptor | Integrase, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
Functional Keywords | integrase, hiv, allini, bi-d, allosteric inhibitor, inhibitor, retrovirus, inlai, ncini, mini, ledgin, viral protein |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 4 |
Total formula weight | 105378.72 |
Authors | Singer, M.R.,Pye, V.E.,Cook, N.J.,Cherepanov, P. (deposition date: 2022-06-01, release date: 2023-02-01, Last modification date: 2024-02-07) |
Primary citation | Singer, M.R.,Dinh, T.,Levintov, L.,Annamalai, A.S.,Rey, J.S.,Briganti, L.,Cook, N.J.,Pye, V.E.,Taylor, I.A.,Kim, K.,Engelman, A.N.,Kim, B.,Perilla, J.R.,Kvaratskhelia, M.,Cherepanov, P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. Mbio, 14:e0356022-e0356022, 2023 Cited by PubMed: 36744954DOI: 10.1128/mbio.03560-22 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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