8A1P

HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D

Summary for 8A1P

Entry DOI	10.2210/pdb8a1p/pdb
Descriptor	Integrase, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
Functional Keywords	integrase, hiv, allini, bi-d, allosteric inhibitor, inhibitor, retrovirus, inlai, ncini, mini, ledgin, viral protein
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	4
Total formula weight	105378.72
Authors	Singer, M.R.,Pye, V.E.,Cook, N.J.,Cherepanov, P. (deposition date: 2022-06-01, release date: 2023-02-01, Last modification date: 2024-02-07)
Primary citation	Singer, M.R.,Dinh, T.,Levintov, L.,Annamalai, A.S.,Rey, J.S.,Briganti, L.,Cook, N.J.,Pye, V.E.,Taylor, I.A.,Kim, K.,Engelman, A.N.,Kim, B.,Perilla, J.R.,Kvaratskhelia, M.,Cherepanov, P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. Mbio, 14:e0356022-e0356022, 2023 Cited by PubMed: 36744954 DOI: 10.1128/mbio.03560-22 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation