3JCA

Core model of the Mouse Mammary Tumor Virus intasome

Summary for 3JCA

• Entry DOI: 10.2210/pdb3jca/pdb
• EMDB information: 6440 6441
• Descriptor: Integrase, 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', ... (5 entities in total)
• Functional Keywords: integration, retrovirus, integrase, intasome, viral protein
• Biological source: Mouse mammary tumor virus (MMTV); More
• Total number of polymer chains: 12
• Total formula weight: 168483.30

Authors

Lyumkis, D.L.,Ballandras-Colas, A.,Brown, M.,Cook, N.J.,Dewdney, T.G.,Demeler, B.,Cherepanov, P.,Engelman, A.N. (deposition date: 2015-11-24, release date: 2016-02-17, Last modification date: 2024-02-21)

• Primary citation: Ballandras-Colas, A.,Brown, M.,Cook, N.J.,Dewdney, T.G.,Demeler, B.,Cherepanov, P.,Lyumkis, D.,Engelman, A.N.; Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.; Nature, 530:358-361, 2016; PubMed: 26887496; DOI: 10.1038/nature16955

Experimental method

ELECTRON MICROSCOPY (4.8 Å)