5KRS
HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid
Summary for 5KRS
Entry DOI | 10.2210/pdb5krs/pdb |
Related | 5KRB |
Descriptor | Integrase, DIMETHYL SULFOXIDE, 3-pyrrol-1-ylthiophene-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | hiv-1 integrase catalytic core domain, p75/ledgf inhibitor, hydrolase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 17446.62 |
Authors | Patel, D.,Bauman, J.D.,Arnold, E. (deposition date: 2016-07-07, release date: 2016-09-28, Last modification date: 2022-03-23) |
Primary citation | Patel, D.,Antwi, J.,Koneru, P.C.,Serrao, E.,Forli, S.,Kessl, J.J.,Feng, L.,Deng, N.,Levy, R.M.,Fuchs, J.R.,Olson, A.J.,Engelman, A.N.,Bauman, J.D.,Kvaratskhelia, M.,Arnold, E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J.Biol.Chem., 291:23569-23577, 2016 Cited by PubMed: 27645997DOI: 10.1074/jbc.M116.753384 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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