6MPV | |
6D05 | | CRYO-EM STRUCTURE OF A PLASMODIUM VIVAX INVASION COMPLEX ESSENTIAL FOR ENTRY INTO HUMAN RETICULOCYTES; TWO MOLECULES OF PARASITE LIGAND, SUBCLASS 2. | | Descriptor: | Transferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, ... | | Authors: | Gruszczyk, J., Huang, R.K., Hong, C., Yu, Z., Tham, W.H. | | Deposit date: | 2018-04-10 | | Release date: | 2018-06-20 | | Last modified: | 2018-07-11 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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6D04 | | CRYO-EM STRUCTURE OF A PLASMODIUM VIVAX INVASION COMPLEX ESSENTIAL FOR ENTRY INTO HUMAN RETICULOCYTES; TWO MOLECULES OF PARASITE LIGAND, SUBCLASS 1. | | Descriptor: | Transferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, ... | | Authors: | Gruszczyk, J., Huang, R.K., Hong, C., Yu, Z., Tham, W.H. | | Deposit date: | 2018-04-10 | | Release date: | 2018-06-20 | | Last modified: | 2018-07-11 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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6D03 | | CRYO-EM STRUCTURE OF A PLASMODIUM VIVAX INVASION COMPLEX ESSENTIAL FOR ENTRY INTO HUMAN RETICULOCYTES; ONE MOLECULE OF PARASITE LIGAND. | | Descriptor: | Transferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, ... | | Authors: | Gruszczyk, J., Huang, R.K., Hong, C., Yu, Z., Tham, W.H. | | Deposit date: | 2018-04-10 | | Release date: | 2018-06-20 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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6C4G | | PLASMEPSIN V FROM PLASMODIUM VIVAX BOUND TO A TRANSITION STATE MIMETIC (WEHI-601) | | Descriptor: | Aspartic protease PM5, N-ACETYL-D-GLUCOSAMINE, benzyl [(6S,7S,10S,13S,18Z)-18-amino-10-cyclohexyl-6-hydroxy-18-imino-7-(2-methylpropyl)-4,9,12-trioxo-1-phenyl-16-oxa-3,8,11,17-tetraazaoctadecan-13-yl]carbamate, ... | | Authors: | Czabotar, P.E., Hodder, A.N., Nguyen, W., Sleebs, B.E., Boddey, J.A., Cowman, A.F. | | Deposit date: | 2018-01-11 | | Release date: | 2018-06-13 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2position of PEXEL peptidomimetics.
Eur J Med Chem, 154, 2018
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6BPE | | PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 6H1 | | Descriptor: | Reticulocyte binding protein 2, putative, Monoclonal antibody 6H1 Fab heavy chain, ... | | Authors: | Gruszczyk, J., Chan, L.J., Tham, W.H. | | Deposit date: | 2017-11-22 | | Release date: | 2018-06-20 | | Last modified: | 2018-07-18 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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6BPD | |
6BPC | | PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 4F7 | | Descriptor: | Reticulocyte binding protein 2, putative, Monoclonal antibody 4F7 Fab heavy chain, ... | | Authors: | Gruszczyk, J., Chan, L.J., Tham, W.H. | | Deposit date: | 2017-11-22 | | Release date: | 2018-06-20 | | Last modified: | 2018-07-18 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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6BPB | |
6BPA | | PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 3E9 | | Descriptor: | Reticulocyte binding protein 2, putative, Monoclonal antibody 3E9 Fab heavy chain, ... | | Authors: | Gruszczyk, J., Chan, L.J., Tham, W.H. | | Deposit date: | 2017-11-22 | | Release date: | 2018-06-20 | | Last modified: | 2018-07-18 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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5UMD | | STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTIMALARIAL DRUG MEFLOQUINE | | Descriptor: | 28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Wong, W., Bai, X.-C., Brown, A., Scheres, S., Baum, J. | | Deposit date: | 2017-01-27 | | Release date: | 2017-03-01 | | Last modified: | 2018-10-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Nat Microbiol, 2, 2017
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5TIK | | STRUCTURAL BASIS FOR INHIBITION OF ERYTHROCYTE INVASION BY ANTIBODIES TO PLASMODIUM FALCIPARUM PROTEIN CYRPA | | Descriptor: | Cysteine-rich protective antigen | | Authors: | Chen, L., Xu, Y., Wang, W., Thompson, J.K., Goddard-Borger, E., Lawrence, M.C., Cowman, A.F. | | Deposit date: | 2016-10-03 | | Release date: | 2017-03-01 | | Last modified: | 2018-03-28 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
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5TIH | | STRUCTURAL BASIS FOR INHIBITION OF ERYTHROCYTE INVASION BY ANTIBODIES TO PLASMODIUM FALCIPARUM PROTEIN CYRPA | | Descriptor: | Cysteine-rich protective antigen, CyRPA antibody Fab Heavy Chain, CyRPA antibody Fab Light Chain, ... | | Authors: | Chen, L., Xu, Y., Wang, W., Thompson, J.K., Goddard-Borger, E., Lawrence, M.C., Cowman, A.F. | | Deposit date: | 2016-10-03 | | Release date: | 2017-03-01 | | Last modified: | 2018-03-28 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
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4ZL4 | | PLASMEPSIN V FROM PLASMODIUM VIVAX BOUND TO A TRANSITION STATE MIMETIC (WEHI-842) | | Descriptor: | Aspartic protease PM5, N-[(benzyloxy)carbonyl]-O-carbamimidamido-L-homoseryl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl}-L-valinamide, SULFATE ION, ... | | Authors: | Czabotar, P.E., Hodder, A.N., Smith, B.J., Sleebs, B.E., Gazdic, M., Boddey, J.A., Cowman, A.F. | | Deposit date: | 2015-05-01 | | Release date: | 2015-07-15 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Nat.Struct.Mol.Biol., 22, 2015
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4WAT | |
3VUV | | CRYSTAL STRUCTURE OF THE MEROZOITE SURFACE PROTEIN MSPDBL2 FROM P. FALCIPARUM BOUND TO ZINC | | Descriptor: | Erythrocyte membrane protein, putative, ZINC ION | | Authors: | Czabotar, P.E., Hodder, A.N., Clarke, O.B., Lin, C.S., Smith, B.J., Cowman, A.F. | | Deposit date: | 2012-07-09 | | Release date: | 2012-08-08 | | Last modified: | 2014-04-16 | | Method: | X-RAY DIFFRACTION (2.114 Å) | | Cite: | Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
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3VUU | | CRYSTAL STRUCTURE OF THE MEROZOITE SURFACE PROTEIN MSPDBL2 FROM P. FALCIPARUM | | Descriptor: | Erythrocyte membrane protein, putative, CHLORIDE ION | | Authors: | Czabotar, P.E., Hodder, A.N., Clarke, O.B., Lin, C.S., Smith, B.J., Cowman, A.F. | | Deposit date: | 2012-07-09 | | Release date: | 2012-08-08 | | Last modified: | 2014-04-16 | | Method: | X-RAY DIFFRACTION (2.093 Å) | | Cite: | Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
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2MCZ | | CR1 SUSHI DOMAINS 1 AND 2 | | Descriptor: | Complement receptor type 1 | | Authors: | Park, H.J., Guariento, M.J., Maciejewski, M., Hauart, R., Tham, W., Cowman, A.F., Schmidt, C.Q., Martens, H., Liszewski, K.M., Hourcade, D., Barlow, P.N., Atkinson, J.P. | | Deposit date: | 2013-08-27 | | Release date: | 2013-11-13 | | Last modified: | 2014-01-22 | | Method: | SOLUTION NMR | | Cite: | Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
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2MCY | | CR1 SUSHI DOMAINS 2 AND 3 | | Descriptor: | Complement receptor type 1 | | Authors: | Park, H.J., Guariento, M.J., Maciejewski, M., Hauart, R., Tham, W., Cowman, A.F., Schmidt, C.Q., Martens, H., Liszewski, K.M., Hourcade, D., Barlow, P.N., Atkinson, J.P. | | Deposit date: | 2013-08-27 | | Release date: | 2013-11-13 | | Last modified: | 2014-01-22 | | Method: | SOLUTION NMR | | Cite: | Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
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