Cryo-electron microscopy structure of Plasmodium falciparum Rh5/CyRPA/Ripr invasion complex

Summary for 6MPV

EMDB information9192
DescriptorCysteine-rich protective antigen, Reticulocyte binding protein 5, PfRipr, ... (4 entities in total)
Functional Keywordsinvasion ligand protein complex, cell invasion
Biological sourcePlasmodium falciparum (isolate 3D7)
Total number of polymer chains4
Total molecular weight80896.8
Wilson, W.,Zhiheng, Y.,Cowman, A.F. (deposition date: 2018-10-08, release date: 2018-12-12, Last modification date: 2019-01-16)
Primary citation
Wong, W.,Huang, R.,Menant, S.,Hong, C.,Sandow, J.J.,Birkinshaw, R.W.,Healer, J.,Hodder, A.N.,Kanjee, U.,Tonkin, C.J.,Heckmann, D.,Soroka, V.,Sogaard, T.M.M.,Jorgensen, T.,Duraisingh, M.T.,Czabotar, P.E.,de Jongh, W.A.,Tham, W.H.,Webb, A.I.,Yu, Z.,Cowman, A.F.
Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.
Nature, 565:118-121, 2019
PubMed: 30542156 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-018-0779-6
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers180 0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures