8W10

Plasmodium vivax PMX-MK7602 inhibitor complex

Summary for 8W10

• Entry DOI: 10.2210/pdb8w10/pdb
• Descriptor: Aspartyl protease, putative, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (7 entities in total)
• Functional Keywords: plasmepsinix, plasmepsinx, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Plasmodium vivax Sal-1
• Total number of polymer chains: 2
• Total formula weight: 87318.89

Authors

Hodder, A.N.,Scally, S.W.,Cowman, A.F. (deposition date: 2024-02-14, release date: 2025-02-26, Last modification date: 2026-03-11)

Primary citation

Favuzza, P.,Palandri, J.,de Lera Ruiz, M.,Bailey, W.,Boyce, C.W.,Danziger, A.,Fawaz, M.V.,Kelly, M.,Murgolo, N.,Robbins, J.A.,Vavrek, M.,Zhao, L.,Lei, Z.,Guo, Z.,Reaksudsan, K.,Steel, R.W.J.,Hodder, A.N.,Ngo, A.,Dziekan, J.M.,Thompson, J.K.,Triglia, T.,Birkinshaw, R.W.,Penington, J.S.,Scally, S.W.,Dans, M.G.,Coyle, R.,Sevilleno, N.,Orban, A.,Feufack-Donfack, L.B.,Popovici, J.,Lee, M.C.S.,Papenfuss, A.,Lowes, K.N.,Sleebs, B.E.,McCarthy, J.S.,McCauley, J.A.,Boddey, J.A.,Olsen, D.B.,Cowman, A.F.
MK-7602: a potent multi-stage dual-targeting antimalarial.
Ebiomedicine, 123:106061-106061, 2026

PubMed Abstract: The global burden of malaria remains substantial, and increasing parasite resistance to current antimalarials necessitates the development of drugs with unique mechanisms of action. This study aimed to develop and characterise a new antimalarial compound targeting Plasmodium aspartic proteases.

PubMed: 41353980
DOI: 10.1016/j.ebiom.2025.106061

Experimental method

X-RAY DIFFRACTION (2.95 Å)