6C4G

Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601)

Summary for 6C4G

Entry DOI	10.2210/pdb6c4g/pdb
Related PRD ID	PRD_002302
Descriptor	Aspartic protease PM5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	malaria, protease, inhibitor, plasmepsin, hydrolase
Biological source	Plasmodium vivax (malaria parasite P. vivax)
Total number of polymer chains	1
Total formula weight	52061.98
Authors	Czabotar, P.E.,Hodder, A.N.,Nguyen, W.,Sleebs, B.E.,Boddey, J.A.,Cowman, A.F. (deposition date: 2018-01-11, release date: 2018-06-13, Last modification date: 2023-10-04)
Primary citation	Nguyen, W.,Hodder, A.N.,de Lezongard, R.B.,Czabotar, P.E.,Jarman, K.E.,O'Neill, M.T.,Thompson, J.K.,Jousset Sabroux, H.,Cowman, A.F.,Boddey, J.A.,Sleebs, B.E. Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2position of PEXEL peptidomimetics. Eur J Med Chem, 154:182-198, 2018 Cited by PubMed: 29800827 DOI: 10.1016/j.ejmech.2018.05.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation