7TBE

Crystal structure of Plasmepsin X from Plasmodium vivax in complex with WM4

Summary for 7TBE

Entry DOI	10.2210/pdb7tbe/pdb
Descriptor	Plasmepsin X, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	aspartyl protease, hydrolase
Biological source	Plasmodium vivax (malaria parasite P. vivax)
Total number of polymer chains	4
Total formula weight	173781.20
Authors	Hodder, A.N.,Christensen, J.B.,Scally, S.W.,Cowman, A.F. (deposition date: 2021-12-21, release date: 2022-05-04, Last modification date: 2023-10-18)
Primary citation	Hodder, A.N.,Christensen, J.,Scally, S.,Triglia, T.,Ngo, A.,Birkinshaw, R.W.,Bailey, B.,Favuzza, P.,Dietrich, M.H.,Tham, W.H.,Czabotar, P.E.,Lowes, K.,Guo, Z.,Murgolo, N.,Lera Ruiz, M.,McCauley, J.A.,Sleebs, B.E.,Olsen, D.,Cowman, A.F. Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax. Structure, 30:947-, 2022 Cited by PubMed: 35460613 DOI: 10.1016/j.str.2022.03.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.35 Å)

Structure validation