4ZL4

Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)

Summary for 4ZL4

Related PRD IDPRD_002168
DescriptorAspartic protease PM5, N-[(benzyloxy)carbonyl]-O-carbamimidamido-L-homoseryl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl}-L-valinamide, SULFATE ION, ... (6 entities in total)
Functional Keywordsmalaria, inhibitor, aspartyl protease, pexel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePlasmodium vivax
Total number of polymer chains2
Total molecular weight103740.47
Authors
Czabotar, P.E.,Hodder, A.N.,Smith, B.J.,Sleebs, B.E.,Gazdic, M.,Boddey, J.A.,Cowman, A.F. (deposition date: 2015-05-01, release date: 2015-07-15, Last modification date: 2017-09-20)
Primary citation
Hodder, A.N.,Sleebs, B.E.,Czabotar, P.E.,Gazdik, M.,Xu, Y.,O'Neill, M.T.,Lopaticki, S.,Nebl, T.,Triglia, T.,Smith, B.J.,Lowes, K.,Boddey, J.A.,Cowman, A.F.
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Nat.Struct.Mol.Biol., 22:590-596, 2015
PubMed: 26214367 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.3061
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.37 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.226501.4%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4zl4
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Molmil generated image of 4zl4
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Molmil generated image of 4zl4
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More Biological unit images

Molmil generated image of 4zl4
no rotation
Molmil generated image of 4zl4
rotated about x axis by 90°
Molmil generated image of 4zl4
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4zl4.pdb1.gz [142.73 KB])
Coordinate files for Biological unit (4zl4.pdb2.gz [141.89 KB])