Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue 4PK A 501 |
| Chain | Residue |
| A | ALA60 |
| A | GLN183 |
| A | ASP313 |
| A | GLY315 |
| A | SER316 |
| A | THR317 |
| A | ILE439 |
| A | EDO505 |
| A | HOH659 |
| A | HOH704 |
| B | ASN342 |
| A | ASP80 |
| B | ASN343 |
| A | GLY82 |
| A | GLN137 |
| A | TYR139 |
| A | CYS140 |
| A | GLU141 |
| A | LEU179 |
| A | PHE180 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | PRO322 |
| A | GLU323 |
| A | GLN433 |
| A | HOH601 |
| A | HOH612 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | LYS51 |
| A | HIS469 |
| A | PRO470 |
| A | HOH602 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | TRP278 |
| A | ARG458 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | SER84 |
| A | GLN137 |
| A | LYS195 |
| A | TYR286 |
| A | 4PK501 |
| A | HOH711 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | ILE338 |
| A | GLN339 |
| A | ASP340 |
| A | MET341 |
| A | MET381 |
| A | CYS382 |
| A | VAL383 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | SER84 |
| A | SER194 |
| A | LYS195 |
| A | GLY198 |
| A | ILE199 |
| A | HOH689 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | TYR233 |
| A | ASP453 |
| A | ARG458 |
| A | HOH693 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | binding site for residue 4PK B 501 |
| Chain | Residue |
| A | ASN342 |
| A | ASN343 |
| B | ALA60 |
| B | ASP80 |
| B | GLY82 |
| B | GLN137 |
| B | TYR139 |
| B | CYS140 |
| B | GLU141 |
| B | LEU179 |
| B | PHE180 |
| B | GLN183 |
| B | TYR288 |
| B | ASP313 |
| B | GLY315 |
| B | SER316 |
| B | THR317 |
| B | HIS320 |
| B | ILE439 |
| B | HOH647 |
| B | HOH673 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | SER83 |
| B | SER84 |
| B | GLN137 |
| B | HOH606 |
| B | HOH645 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | PRO322 |
| B | GLU323 |
| B | GLN433 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| B | LYS51 |
| B | TYR53 |
| B | HIS469 |
| B | PRO470 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 505 |
| Chain | Residue |
| B | TRP278 |
| B | ARG458 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | SER84 |
| B | SER194 |
| B | LYS195 |
| B | GLY198 |
| B | ILE199 |
| B | HOH679 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | VAL276 |
| B | TYR233 |
| B | ALA273 |
| B | GLU274 |
| B | LYS275 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for residue 4PF B 508 |
| Chain | Residue |
| B | CYS117 |
| B | CYS117 |
| B | GLU118 |
| B | GLU120 |
| B | GLU121 |
| B | GLU121 |
| B | CYS122 |
| B | CYS122 |
| B | LEU126 |
| B | CYS128 |
| B | CYS128 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDTGSSSLSF |
| Chain | Residue | Details |
| A | LEU77-PHE88 | |
| A | MET310-ILE321 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP80 | |
| A | ASP313 | |
| B | ASP80 | |
| B | ASP313 | |
