Author results

3R9O
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-143
Descriptor:Cyclin-dependent kinase 2, 4-amino-N-(3,5-difluorophenyl)-2-[(4-sulfamoylphenyl)amino]-1,3-thiazole-5-carboxamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-03-25
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RAH
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-22
Descriptor:Cyclin-dependent kinase 2, [4-amino-2-(cyclohexylamino)-1,3-thiazol-5-yl](naphthalen-2-yl)methanone
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-03-28
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RAI
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CDK2 IN COMPLEX WITH INHIBITOR KVR-1-160
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 4-{[3-(morpholin-4-yl)propyl]amino}-5-nitro-2-[(pyridin-3-ylmethyl)amino]benzamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-03-28
Release date:2012-08-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening
To be Published
3RAK
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-32
Descriptor:Cyclin-dependent kinase 2, 4-[(4-amino-5-benzoyl-1,3-thiazol-2-yl)amino]benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-03-28
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RAL
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-34
Descriptor:Cyclin-dependent kinase 2, 4-{[4-amino-5-(3-methoxybenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-03-28
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RJC
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CDK2 IN COMPLEX WITH INHIBITOR L4-12
Descriptor:Cyclin-dependent kinase 2, {4-amino-2-[(3-fluorophenyl)amino]-1,3-thiazol-5-yl}(phenyl)methanone
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-15
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RK5
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-72
Descriptor:Cyclin-dependent kinase 2, 4-{[4-amino-5-(pyridin-3-ylcarbonyl)-1,3-thiazol-2-yl]amino}benzoic acid
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-17
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RK7
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-71
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 4-{[4-amino-5-(pyridin-3-ylcarbonyl)-1,3-thiazol-2-yl]amino}benzamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-17
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RK9
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-74
Descriptor:Cyclin-dependent kinase 2, [4-amino-2-(propan-2-ylamino)-1,3-thiazol-5-yl](pyridin-3-yl)methanone
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-17
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RKB
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-73
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, [4-amino-2-(cyclohexylamino)-1,3-thiazol-5-yl](pyridin-3-yl)methanone
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-17
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RM6
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CDK2 IN COMPLEX WITH INHIBITOR KVR-2-80
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 2-{[(2-aminopyrimidin-5-yl)methyl]amino}-5-nitro-4-{[2-(piperazin-1-yl)ethyl]amino}benzamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-20
Release date:2012-08-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening
To be Published
3RM7
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CDK2 IN COMPLEX WITH INHIBITOR KVR-1-91
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 2-[(4-hydroxybenzyl)amino]-5-nitrobenzamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-20
Release date:2012-08-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening
To be Published
3RMF
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-33
Descriptor:Cyclin-dependent kinase 2, 4-{[4-amino-5-(naphthalen-2-ylcarbonyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-20
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RNI
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CDK2 IN COMPLEX WITH INHIBITOR RC-3-86
Descriptor:Cyclin-dependent kinase 2, 3-[(4-amino-5-benzoyl-1,3-thiazol-2-yl)amino]benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-22
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3ROY
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CDK2 IN COMPLEX WITH INHIBITOR KVR-1-154
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 4-(hexylamino)-5-nitro-2-[(pyridin-3-ylmethyl)amino]benzamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-26
Release date:2012-08-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening
To be Published
3RPO
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CDK2 IN COMPLEX WITH INHIBITOR KVR-1-156
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 4-({4-carbamoyl-2-nitro-5-[(pyridin-3-ylmethyl)amino]phenyl}amino)butanoic acid
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-27
Release date:2012-08-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening
To be Published
3RPR
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-49
Descriptor:Cyclin-dependent kinase 2, [4-amino-2-(phenylamino)-1,3-thiazol-5-yl][3-(trifluoromethyl)phenyl]methanone
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-27
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RPV
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-88
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 4-{[4-amino-5-(3-aminobenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-27
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RPY
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-40
Descriptor:Cyclin-dependent kinase 2, 4-amino-2-[(4-sulfamoylphenyl)amino]-1,3-thiazole-5-carboxamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-04-27
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3RZB
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-23
Descriptor:Cyclin-dependent kinase 2, 4-amino-2-(phenylamino)-1,3-thiazole-5-carboxamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-05-11
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3S00
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CDK2 IN COMPLEX WITH INHIBITOR L4-14
Descriptor:Cyclin-dependent kinase 2, [4-amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](5-chlorothiophen-2-yl)methanone
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-05-12
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3S0O
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CDK2 IN COMPLEX WITH INHIBITOR RC-1-138
Descriptor:Cyclin-dependent kinase 2, [4-amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](pyridin-2-yl)methanone
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-05-13
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3S1H
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CDK2 IN COMPLEX WITH INHIBITOR RC-2-39
Descriptor:Cyclin-dependent kinase 2, 4-{[4-amino-5-(4-methoxybenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-05-15
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
3SQQ
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CDK2 IN COMPLEX WITH INHIBITOR RC-3-96
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 4-{[4-amino-5-(2-methylbenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-07-06
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013
4GCJ
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CDK2 IN COMPLEX WITH INHIBITOR RC-3-89
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 4-{[4-amino-5-(2-nitrobenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2012-07-30
Release date:2012-10-31
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J.Med.Chem., 56, 2013