7OJH
| ABCG2 topotecan turnover-1 state | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | Deposit date: | 2021-05-15 | Release date: | 2021-07-21 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OJI
| ABCG2 topotecan turnover-2 state | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | Deposit date: | 2021-05-16 | Release date: | 2021-07-21 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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6G1S
| CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-21 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6G19
| CryoEM structure of the MDA5-dsRNA filament with 74-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-20 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6H66
| CryoEM structure of the MDA5-dsRNA filament with 93 degree twist and without nucleotide | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-07-26 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6H61
| CryoEM structure of the MDA5-dsRNA filament with 89 degree twist and without nucleotide | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-07-25 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.02 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GJZ
| CryoEM structure of the MDA5-dsRNA filament in complex with AMPPNP | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-05-17 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GKH
| CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-05-21 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6G1X
| CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-22 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GKM
| CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-05-21 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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5JHE
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4JVS
| Crystal structure of LepB GAP domain from Legionella drancourtii in complex with Rab1-GDP and AlF3 | Descriptor: | ACETIC ACID, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Yu, Q, Yao, Q, Wang, D.-C, Shao, F. | Deposit date: | 2013-03-26 | Release date: | 2013-05-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.783 Å) | Cite: | Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP Cell Res., 23, 2013
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7NIC
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7NIQ
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7NGA
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7BKQ
| CryoEM structure of MDA5-dsRNA filament in complex with ADP with 92-degree helical twist | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Isoform 2 of Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), ... | Authors: | Yu, Q, Modis, Y. | Deposit date: | 2021-01-17 | Release date: | 2021-11-17 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
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7OJ8
| ABCG2 E1S turnover-2 state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | Authors: | Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | Deposit date: | 2021-05-14 | Release date: | 2021-07-21 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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8ZL9
| ASFV p72 in complex with Fab G6 | Descriptor: | B646L, G6 Heavy chain, G6 Light chain | Authors: | Wang, X, Fu, W, Yu, Q. | Deposit date: | 2024-05-17 | Release date: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (4.36 Å) | Cite: | p72 antigenic mapping reveals a potential supersite of vulnerability for African swine fever virus. Cell Discov, 10, 2024
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8BHT
| ABCG2 turnover-1 state with tariquidar bound | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | Authors: | Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. | Deposit date: | 2022-10-31 | Release date: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proc.Natl.Acad.Sci.USA, 120, 2023
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8BI0
| ABCG2 turnover-2 state with tariquidar bound | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | Authors: | Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. | Deposit date: | 2022-11-01 | Release date: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proc.Natl.Acad.Sci.USA, 120, 2023
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3R2W
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7KL5
| Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues: Phe4246 to Val4271 | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Calmodulin-1, ... | Authors: | Fisher, A.J, Ames, J.B, Yu, Q. | Deposit date: | 2020-10-29 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246-Val4271 Reveals a Fifth Calcium Binding Site. Biochemistry, 60, 2021
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6DRF
| Structure of human Retinal Degeneration 3(RD3) Protein | Descriptor: | Protein RD3 | Authors: | Yu, Q, Lim, S, Peshenko, I, Cudia, D, Dizhoor, A.M, Ames, J.B. | Deposit date: | 2018-06-11 | Release date: | 2019-02-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Retinal degeneration 3 (RD3) protein, a retinal guanylyl cyclase regulator, forms a monomeric and elongated four-helix bundle. J. Biol. Chem., 294, 2019
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6BHN
| Red Light-Absorbing State of NpR6012g4, a Red/Green Cyanobacteriochrome | Descriptor: | Methyl-accepting chemotaxis sensory transducer with phytochrome sensor, PHYCOCYANOBILIN | Authors: | Yu, Q, Lim, S, Rockwell, N.C, Martin, S.S, Lagarias, J.C, Ames, J.B. | Deposit date: | 2017-10-31 | Release date: | 2018-04-18 | Last modified: | 2019-12-04 | Method: | SOLUTION NMR | Cite: | Correlating structural and photochemical heterogeneity in cyanobacteriochrome NpR6012g4. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8Y3Q
| ASFV p72 in complex with Fab F11 | Descriptor: | B646L, Heavy chain of F11, Light chain of F11 | Authors: | Wang, X, Fu, W, Yu, Q. | Deposit date: | 2024-01-29 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | p72 antigenic mapping reveals a potential supersite of vulnerability for African swine fever virus. Cell Discov, 10, 2024
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