6GKM

CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM)

Summary for 6GKM

• Entry DOI: 10.2210/pdb6gkm/pdb
• Related: 6G19 6G1S 6G1X 6GJZ 6GKH
• EMDB information: 0012 0023 0024 4338 4340 4341
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), RNA (5'-R(P*CP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3'), ... (5 entities in total)
• Functional Keywords: protein-rna complex, helical filament, atpase, innate immune receptor, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 123727.50

Authors

Yu, Q.,Qu, K.,Modis, Y. (deposition date: 2018-05-21, release date: 2018-11-21, Last modification date: 2020-11-18)

• Primary citation: Yu, Q.,Qu, K.,Modis, Y.; Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.; Mol. Cell, 72:999-1012.e6, 2018; PubMed: 30449722; DOI: 10.1016/j.molcel.2018.10.012

Experimental method

ELECTRON MICROSCOPY (3.87 Å)