6GKM
CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Interferon-induced helicase C domain-containing protein 1 | polymer | 1007 | 114214.5 | 1 | UniProt (Q8R5F7) Pfam (PF16739) Pfam (PF00619) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) In PDB | Mus musculus (Mouse) | Helicase with 2 CARD domains,Helicard,Interferon induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,RIG-I-like receptor 2,RLR-2 |
| 2 | X | RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3') | polymer | 14 | 4587.9 | 1 | Pseudomonas phage phi6 | ||
| 3 | Y | RNA (5'-R(P*CP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') | polymer | 14 | 4352.6 | 1 | Pseudomonas phage phi6 | ||
| 4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) |
Sequence modifications
A: 1 - 1025 (UniProt: Q8R5F7)
| PDB | External Database | Details |
|---|---|---|
| - | Asp 646 | deletion |
| - | Lys 647 | deletion |
| - | Ser 648 | deletion |
| - | Asp 649 | deletion |
| - | Asp 650 | deletion |
| - | Glu 651 | deletion |
| - | Ala 652 | deletion |
| - | Ser 653 | deletion |
| - | Ser 654 | deletion |
| - | Cys 655 | deletion |
| - | Asn 656 | deletion |
| - | Asp 657 | deletion |
| - | Gln 658 | deletion |
| - | Leu 659 | deletion |
| - | Lys 660 | deletion |
| - | Gly 661 | deletion |
| - | Asp 662 | deletion |
| - | Val 663 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 123154.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 572.6 | |
| All* | Total formula weight | 123727.5 |
