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1HZH
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BU of 1hzh by Molmil
CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN
Descriptor: IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saphire, E.O, Burton, D.R, Wilson, I.A.
Deposit date:2001-01-24
Release date:2001-08-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science, 293, 2001
1N0X
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BU of 1n0x by Molmil
Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, B2.1 peptide, GLYCEROL, ...
Authors:Saphire, E.O, Montero, M, Menendez, A, Irving, M.B, Zwick, M.B, Parren, P.W.H.I, Burton, D.R, Scott, J.K, Wilson, I.A.
Deposit date:2002-10-15
Release date:2004-04-13
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope
To be Published
3S88
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BU of 3s88 by Molmil
Crystal structure of Sudan Ebolavirus Glycoprotein (strain Gulu) bound to 16F6
Descriptor: 16F6 - Heavy chain, 16F6 - Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saphire, E.O, Dias, J.M, Bale, S.
Deposit date:2011-05-27
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.351 Å)
Cite:A shared structural solution for neutralizing ebolaviruses.
Nat.Struct.Mol.Biol., 18, 2011
6P95
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BU of 6p95 by Molmil
Structure of Lassa virus glycoprotein in complex with Fab 25.6A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saphire, E.O, Hastie, K.M.
Deposit date:2019-06-09
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Cell, 178, 2019
6P91
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BU of 6p91 by Molmil
Structure of Lassa virus glycoprotein bound to Fab 18.5C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 18.5C Antibody heavy chain, ...
Authors:Saphire, E.O, Hastie, K.M.
Deposit date:2019-06-09
Release date:2019-08-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Cell, 178, 2019
3VE0
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BU of 3ve0 by Molmil
Crystal structure of Sudan Ebolavirus Glycoprotein (strain Boniface) bound to 16F6
Descriptor: 16F6 Antibody chain A, 16F6 Antibody chain B, Envelope glycoprotein, ...
Authors:Saphire, E.O, Bale, S, Dias, J.M.
Deposit date:2012-01-06
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.353 Å)
Cite:Structural basis for differential neutralization of ebolaviruses.
Viruses, 4, 2012
6EA5
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BU of 6ea5 by Molmil
Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-15878 Fab Heavy Chain, ...
Authors:King, L.B, West, B.R, Moyer, C.L, Fusco, M.L, Milligan, J.C, Hui, S, Saphire, E.O.
Deposit date:2018-08-02
Release date:2018-09-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4.75 Å)
Cite:Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope.
MBio, 9, 2018
3KS8
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BU of 3ks8 by Molmil
Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA
Descriptor: 5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3', 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3', Polymerase cofactor VP35
Authors:Kimberlin, C.R, Bornholdt, Z.A, Li, S, Woods, V.L, Macrae, I.J, Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
2QHR
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BU of 2qhr by Molmil
Crystal structure of the 13F6-1-2 Fab fragment bound to its Ebola virus glycoprotein peptide epitope.
Descriptor: 13F6-1-2 Fab fragment V lambda x light chain, 13F6-1-2 Fab fragment heavy chain, Envelope glycoprotein peptide
Authors:Lee, J.E, Kuehne, A, Abelson, D.M, Fusco, M.L, Hart, M.K, Saphire, E.O.
Deposit date:2007-07-02
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.
J.Mol.Biol., 375, 2008
3KS4
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BU of 3ks4 by Molmil
Crystal structure of Reston ebolavirus VP35 RNA binding domain
Descriptor: Polymerase cofactor VP35
Authors:Kimberlin, C.R, Bornholdt, Z.A, Li, S, Woods, V.L, Macrae, I.J, Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
6OZ9
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BU of 6oz9 by Molmil
Ebola virus glycoprotein in complex with EBOV-520 Fab
Descriptor: EBOV-520 Fab heavy chain, EBOV-520 Fab light chain, Envelope glycoprotein, ...
Authors:Milligan, J.C, Altman, P.X, Hui, S, Hastie, K.M, Gilchuk, P, Crowe, J.E, Saphire, E.O.
Deposit date:2019-05-15
Release date:2020-03-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.462 Å)
Cite:Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Immunity, 52, 2020
3CSY
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BU of 3csy by Molmil
Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein GP1, ...
Authors:Lee, J.E, Fusco, M.L, Hessell, A.J, Oswald, W.B, Burton, D.R, Saphire, E.O.
Deposit date:2008-04-10
Release date:2008-07-08
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Nature, 454, 2008
5T3W
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BU of 5t3w by Molmil
Marburg virus VP30 bound to nucleoprotein
Descriptor: Fusion protein of Nucleoprotein and Minor nucleoprotein VP30
Authors:Kirchdoerfer, R.K, Moyer, C.L, Abelson, D.M, Saphire, E.O.
Deposit date:2016-08-26
Release date:2016-09-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis.
Plos Pathog., 12, 2016
5T3T
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BU of 5t3t by Molmil
Ebola virus VP30 CTD bound to nucleoprotein
Descriptor: Fusion protein of Nucleoprotein and Minor nucleoprotein VP30, SULFATE ION
Authors:Kirchdoerfer, R.N, Moyer, C.L, Abelson, D.M, Saphire, E.O.
Deposit date:2016-08-26
Release date:2016-09-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis.
Plos Pathog., 12, 2016
3INU
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BU of 3inu by Molmil
Crystal structure of an unbound KZ52 neutralizing anti-Ebolavirus antibody.
Descriptor: GLYCEROL, KZ52 antibody fragment heavy chain, KZ52 antibody fragment light chain, ...
Authors:Lee, J.E, Fusco, M.L, Abelson, D.M, Hessell, A.J, Burton, D.R, Saphire, E.O.
Deposit date:2009-08-12
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Acta Crystallogr.,Sect.D, 65, 2009
7RPU
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BU of 7rpu by Molmil
Crystal Structure of Protective Human Antibody 3A6 Fab Against Ebola Virus with GP Stalk/MPER Epitope Peptide
Descriptor: 3A6 Fab heavy chain, 3A6 Fab light chain, GP2 epitope peptide
Authors:Salie, Z.L, Saphire, E.O, Davis, C.W, Ahmed, R.
Deposit date:2021-08-04
Release date:2022-07-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Protection against Ebola virus disease and neutralization mechanism of a survivor's anti-stalk-MPER antibody
To Be Published
7RPT
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BU of 7rpt by Molmil
Crystal Structure of Protective Human Antibody 3A6 Fab Against Ebola Virus
Descriptor: 3A6 Fab heavy chain, 3A6 Fab light chain
Authors:Salie, Z.L, Saphire, E.O, Davis, C.W, Ahmed, R.
Deposit date:2021-08-04
Release date:2022-07-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Protection against Ebola virus disease and neutralization mechanism of a survivor's anti-stalk/MPER antibody
To Be Published
2Y6S
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BU of 2y6s by Molmil
Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope
Descriptor: ENVELOPE GLYCOPROTEIN, HEAVY CHAIN, LIGHT CHAIN
Authors:Olal, D.O, Kuehne, A, Lee, J.E, Bale, S, Dye, J.M, Saphire, E.O.
Deposit date:2011-01-25
Release date:2012-01-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an Ebola Virus-Protective Antibody in Complex with its Mucin-Domain Linear Epitope.
J.Virol., 86, 2012
7N6P
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BU of 7n6p by Molmil
Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab
Descriptor: 1C3 Fab heavy chain, 1C3 Fab light chain
Authors:Milligan, J.C, Yu, X, Buck, T, Saphire, E.O.
Deposit date:2021-06-08
Release date:2022-04-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Cell, 185, 2022
4LDB
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BU of 4ldb by Molmil
Crystal Structure of Ebola Virus VP40 Dimer
Descriptor: Matrix protein VP40
Authors:Bornholdt, Z.A, Ableson, D.M, Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LG2
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BU of 4lg2 by Molmil
Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA
Descriptor: Polymerase cofactor, dsRNA
Authors:Bale, S, Julien, J.-P, Bornholdt, Z.A, Krois, A.S, Wilson, I.A, Saphire, E.O.
Deposit date:2013-06-27
Release date:2013-07-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism.
J.Virol., 87, 2013
4LD8
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BU of 4ld8 by Molmil
Crystal Structure of Dimeric Sudan Virus VP40
Descriptor: Matrix protein VP40
Authors:Bornholdt, Z.A, Ableson, D.M, Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4FVU
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BU of 4fvu by Molmil
Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease
Descriptor: MAGNESIUM ION, Nucleoprotein, RNA (5'-R(*CP*UP*CP*CP*CP*UP*CP*C)-3'), ...
Authors:Hastie, K.M, King, L.B, Zandonatti, M.A, Saphire, E.O.
Deposit date:2012-06-29
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease.
Plos One, 7, 2012
4GHA
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BU of 4gha by Molmil
Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA
Descriptor: Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3')
Authors:Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012
4GH9
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BU of 4gh9 by Molmil
Crystal structure of Marburg virus VP35 RNA binding domain
Descriptor: ACETATE ION, Polymerase cofactor VP35
Authors:Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012

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PDB entries from 2024-09-18

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