7YOA
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1DFN
| CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION | Descriptor: | DEFENSIN HNP-3 | Authors: | Hill, C.P, Yee, J, Selsted, M.E, Eisenberg, D. | Deposit date: | 1991-01-18 | Release date: | 1992-07-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science, 251, 1991
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6KRA
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3QTE
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6DMQ
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4RBW
| Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant) | Descriptor: | CHLORIDE ION, Defensin-5, SULFATE ION | Authors: | Pazgier, M, Gohain, N, Tolbert, W.D. | Deposit date: | 2014-09-13 | Release date: | 2015-07-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58, 2015
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4RBX
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6DMM
| Crystal structure of the G23A mutant of human alpha defensin HNP4. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4, SULFATE ION | Authors: | Gohain, N, Tolbert, W.D, Pazgier, M. | Deposit date: | 2018-06-05 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Systematic mutational analysis of human neutrophil alpha-defensin HNP4. Biochim Biophys Acta Biomembr, 1861, 2019
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2K1I
| Synthesis, Structure and Activities of an Oral Mucosal Alpha-Defensin from Rhesus Macaque | Descriptor: | Mucosal Alpha-Defensin | Authors: | Vasudevan, S.V, Yuan, J, Osapay, G, Tran, P, Tai, K, Selsted, M, Cocco, M.J. | Deposit date: | 2008-03-05 | Release date: | 2008-10-28 | Last modified: | 2018-01-24 | Method: | SOLUTION NMR | Cite: | Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. J.Biol.Chem., 283, 2008
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2KHT
| NMR Structure of human alpha defensin HNP-1 | Descriptor: | Neutrophil defensin 1 | Authors: | Zhang, Y, Li, S, Doherty, T.F, Lubkowski, J, Lu, W, Li, J, Barinka, C, Hong, M. | Deposit date: | 2009-04-11 | Release date: | 2010-02-09 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR. J.Mol.Biol., 397, 2010
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5CUJ
| Crystal structure of Human Defensin-5 Y27A mutant crystal form 2. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Tolbert, W.D, Gohain, N, Pazgier, M. | Deposit date: | 2015-07-24 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity, 2018
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5CUI
| Crystal structure of Human Defensin-5 R28A mutant. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, ... | Authors: | Tolbert, W.D, Gohain, N, Pazgier, M. | Deposit date: | 2015-07-24 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity, 2018
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5CUM
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4E82
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4DU0
| Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant) | Descriptor: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 | Authors: | Wu, X, Lu, W, Pazgier, M. | Deposit date: | 2012-02-21 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1 J.Biol.Chem., 287, 2012
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4E83
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4LBF
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4E86
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4LB1
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4LBB
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4LB7
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3GNY
| Crystal structure of human alpha-defensin 1 (HNP1) | Descriptor: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 | Authors: | Pazgier, M, Lu, W.-Y. | Deposit date: | 2009-03-18 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Through the looking glass, mechanistic insights from enantiomeric human defensins. J.Biol.Chem., 284, 2009
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3H6C
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3HJ2
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3I5W
| Crystal structure of human alpha-defensin 5 (mutant R13H) | Descriptor: | CHLORIDE ION, CITRATE ANION, Defensin-5 | Authors: | Pazgier, M, Lu, W. | Deposit date: | 2009-07-06 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5 Febs Lett., 583, 2009
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