4LB1

Crystal structure of human alpha-defensin 1 (HNP1) Y16A/F28A mutant

Summary for 4LB1

Entry DOI	10.2210/pdb4lb1/pdb
Related	3GNY 4LB7 4LBB 4LBF
Descriptor	Neutrophil defensin 1 (2 entities in total)
Functional Keywords	antimicrobial peptide, human alpha defensin 1, human neutrophil peptide 1, hnp1, antibiotic, antimicrobial, antiviral defense, defensin, disulfide bond, fungicide, phosphoprotein, secreted, antimicrobial protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P59665
Total number of polymer chains	4
Total formula weight	13135.68
Authors	Tolbert, W.D.,Wu, X.,Pazgier, M. (deposition date: 2013-06-20, release date: 2013-11-27, Last modification date: 2023-09-20)
Primary citation	Zhao, L.,Tolbert, W.D.,Ericksen, B.,Zhan, C.,Wu, X.,Yuan, W.,Li, X.,Pazgier, M.,Lu, W. Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8:e78937-e78937, 2013 Cited by PubMed: 24236072 DOI: 10.1371/journal.pone.0078937 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation