3QTE

Crystal structure of human alpha-defensin 6 (H27W mutant)

Summary for 3QTE

Entry DOI	10.2210/pdb3qte/pdb
Related	1ZMP 1ZMQ
Descriptor	Defensin-6, CHLORIDE ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	antimicrobial protein, paneth cells defensin, hd6, human alpha defensin
Biological source	Homo sapiens (human)
Cellular location	Secreted: Q01524
Total number of polymer chains	4
Total formula weight	15232.47
Authors	Pazgier, M.,Lu, W. (deposition date: 2011-02-22, release date: 2012-01-11, Last modification date: 2023-09-13)
Primary citation	Chu, H.,Pazgier, M.,Jung, G.,Nuccio, S.P.,Castillo, P.A.,de Jong, M.F.,Winter, M.G.,Winter, S.E.,Wehkamp, J.,Shen, B.,Salzman, N.H.,Underwood, M.A.,Tsolis, R.M.,Young, G.M.,Lu, W.,Lehrer, R.I.,Baumler, A.J.,Bevins, C.L. Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science, 337:477-481, 2012 Cited by PubMed: 22722251 DOI: 10.1126/science.1218831 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.949 Å)

Structure validation