4DU0
Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant)
Summary for 4DU0
Entry DOI | 10.2210/pdb4du0/pdb |
Related | 3GNY 3HJ2 3HJD |
Descriptor | Neutrophil defensin 1, GLYCEROL, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | cysteine rich antimicrobial peptide, alpha-defensin, hnp1, human alpha-defensin 1, g17a mutant, defensin fold, antimicrobial peptide, human neutrophils, antibiotic |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P59665 |
Total number of polymer chains | 4 |
Total formula weight | 14303.83 |
Authors | Wu, X.,Lu, W.,Pazgier, M. (deposition date: 2012-02-21, release date: 2012-04-11, Last modification date: 2023-09-13) |
Primary citation | Zhao, L.,Ericksen, B.,Wu, X.,Zhan, C.,Yuan, W.,Li, X.,Pazgier, M.,Lu, W. Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1 J.Biol.Chem., 287:18900-18912, 2012 Cited by PubMed: 22496447DOI: 10.1074/jbc.M112.355255 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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