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7N7J	Crystal Structure of PI5P4KIIAlpha complex with AMPPNP Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ... Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7M	Crystal Structure of PI5P4KIIAlpha complex with BI-2536 Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7K	Crystal Structure of PI5P4KIIAlpha complex with AMPPNP Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ... Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7L	Crystal Structure of PI5P4KIIAlpha complex with BI-D1870 Descriptor: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N80	Crystal Structure of PI5P4KIIBeta Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Authors: Chen, S, Ha, Y. Deposit date: 2021-06-11 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N71	Crystal Structure of PI5P4KIIAlpha Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-09 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
3PDH	Structure of Sir2Tm bound to a propionylated peptide Descriptor: Cellular tumor antigen p53 18-residue peptide, NAD-dependent deacetylase, ZINC ION Authors: Wolberger, C, Bheda, P. Deposit date: 2010-10-22 Release date: 2011-01-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of Sir2Tm bound to a propionylated peptide. Protein Sci., 20, 2011
1RV1	CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR Descriptor: CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE, Ubiquitin-protein ligase E3 Mdm2 Authors: Lukacs, C, Kammlott, U, Graves, B. Deposit date: 2003-12-12 Release date: 2004-01-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science, 303, 2004
5MNJ	Structure of MDM2-MDMX-UbcH5B-ubiquitin complex Descriptor: E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, Protein Mdm4, ... Authors: Klejnot, M, Huang, D.T. Deposit date: 2016-12-13 Release date: 2017-05-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nat. Struct. Mol. Biol., 24, 2017
4BUZ	SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD Descriptor: (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, 1,2-ETHANEDIOL, 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, ... Authors: Weyand, M, Lakshminarasimhan, M, Gertz, M, Steegborn, C. Deposit date: 2013-06-24 Release date: 2013-07-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110, 2013
4BV2	CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE Descriptor: (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, CELLULAR TUMOR ANTIGEN P53, ... Authors: Gertz, M, Weyand, M, Steegborn, C. Deposit date: 2013-06-24 Release date: 2013-07-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110, 2013
3U15	Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443 Descriptor: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, Protein Mdm4, SULFATE ION Authors: Lukacs, C.M, Janson, C.A, Graves, B.J. Deposit date: 2011-09-29 Release date: 2012-06-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc.Natl.Acad.Sci.USA, 109, 2012
3VBG	Structure of hDM2 with Dimer Inducing Indolyl Hydantoin RO-2443 Descriptor: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, E3 ubiquitin-protein ligase Mdm2 Authors: Lukacs, C.M, Janson, C.A, Graves, B.J. Deposit date: 2012-01-02 Release date: 2012-06-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc.Natl.Acad.Sci.USA, 109, 2012
4GUQ	Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element Descriptor: DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3'), Tumor protein p73, ZINC ION Authors: Ethayathulla, A.S, Nguyen, H.T, Viadiu, H. Deposit date: 2012-08-29 Release date: 2013-08-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res., 41, 2013
3LNJ	Crystal structure of human MDM2 in complex with D-peptide inhibitor (DPMI-alpha) Descriptor: CHLORIDE ION, D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, ... Authors: Pazgier, M, Lu, W. Deposit date: 2010-02-02 Release date: 2010-03-09 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A left-handed solution to peptide inhibition of the p53-MDM2 interaction. Angew.Chem.Int.Ed.Engl., 49, 2010
3FDO	Structure of human MDMX in complex with high affinity peptide Descriptor: MAGNESIUM ION, Protein Mdm4, Synthetic high affinity peptide Authors: Czarna, A.L, Popowicz, G.M, Holak, T.A. Deposit date: 2008-11-26 Release date: 2008-12-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.4 Å) Cite: High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle, 8, 2009
3G03	Structure of human MDM2 in complex with high affinity peptide Descriptor: E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide Authors: Czarna, A.L, Popowicz, G.M, Holak, T.A. Deposit date: 2009-01-27 Release date: 2009-04-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle, 8, 2009
7PC6	DNA-binding domain of a p53 homolog from the hydrothermal vent annelid Alvinella pompejana Descriptor: 1,2-ETHANEDIOL, DNA-binding domain, ZINC ION Authors: Balourdas, D.-I, Knapp, S, Soussi, T, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2021-08-03 Release date: 2022-03-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog. Cell Death Dis, 13, 2022
2D82	Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association Descriptor: 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE, CREB-binding protein Authors: Sachchidanand, Resnick-Silverman, L, Yan, S, Mujtaba, S, Liu, W.J, Zeng, L, Manfredi, J.J, Zhou, M.M. Deposit date: 2005-12-01 Release date: 2006-04-04 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Target structure-based discovery of small molecules that block human p53 and CREB binding protein association Chem.Biol., 13, 2006
2AXI	HDM2 in complex with a beta-hairpin Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, ... Authors: Mittl, P.R.E, Fasan, R, Robinson, J, Gruetter, M.G. Deposit date: 2005-09-05 Release date: 2006-03-21 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction. Chembiochem, 7, 2006
2B29	N-terminal domain of the RPA70 subunit of human replication protein A. Descriptor: Replication protein A 70 kDa DNA-binding subunit Authors: Bochkareva, E, Kaustov, L, Ayed, A, Okorokov, A, Milner, J, Arrowsmith, C.H, Bochkarev, A. Deposit date: 2005-09-18 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A. Proc.Natl.Acad.Sci.Usa, 102, 2005
2JTX	NMR structure of the TFIIE-alpha carboxyl terminus Descriptor: Transcription initiation factor IIE subunit alpha Authors: Di Lello, P, Omichinski, J.G. Deposit date: 2007-08-08 Release date: 2007-12-11 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH. Proc.Natl.Acad.Sci.Usa, 105, 2008
2NB1	P63/p73 hetero-tetramerisation domain Descriptor: Tumor protein 63, Tumor protein p73 Authors: Gebel, J, Buchner, L, Loehr, F.M, Luh, L.M, Coutandin, D, Guentert, P, Doetsch, V. Deposit date: 2016-01-19 Release date: 2016-12-07 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Mechanism of TAp73 inhibition by Delta Np63 and structural basis of p63/p73 hetero-tetramerization. Cell Death Differ., 23, 2016
5HOC	p73 homo-tetramerization domain mutant II Descriptor: Tumor protein p73 Authors: Coutandin, D, Krojer, T, Salah, E, Mathea, S, Sumyk, M, Knapp, S, Dotsch, V. Deposit date: 2016-01-19 Release date: 2016-10-19 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.36007786 Å) Cite: Mechanism of TAp73 inhibition by Delta Np63 and structural basis of p63/p73 hetero-tetramerization. Cell Death Differ., 23, 2016
4RXZ	Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide Descriptor: 12-MER PEPTIDE INHIBITOR, Protein Mdm4 Authors: Pazgier, M, Gohain, N, Tolbert, W.D. Deposit date: 2014-12-12 Release date: 2015-07-22 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene, 35, 2016

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