Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association

Summary for 2D82

DescriptorCREB-binding protein, 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE (2 entities in total)
Functional Keywords3, 4, bromodomain, creb, cbp, p53, chemical ligand, 9-acetyl-2, 9-tetrahydro-carbazol-1-one, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q92793
Total number of polymer chains1
Total molecular weight14645.81
Sachchidanand,Resnick-Silverman, L.,Yan, S.,Mujtaba, S.,Liu, W.J.,Zeng, L.,Manfredi, J.J.,Zhou, M.M. (deposition date: 2005-12-01, release date: 2006-04-04, Last modification date: 2011-07-13)
Primary citation
Sachchidanand,Resnick-Silverman, L.,Yan, S.,Mutjaba, S.,Liu, W.J.,Zeng, L.,Manfredi, J.J.,Zhou, M.M.
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
Chem.Biol., 13:81-90, 2006
PubMed: 16426974 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2005.10.014
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers414.2%18.6%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload