NMR Structure of CBP Bromodomain in complex with p53 peptide

Summary for 1JSP

Descriptortumor protein p53, CREB-BINDING PROTEIN (2 entities in total)
Functional Keywordsbromodomain, cbp, nmr structure., dna binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Cytoplasm Q92793
Total number of polymer chains2
Total molecular weight16825.44
He, Y.,Mujtaba, S.,Zeng, L.,Yan, S.,Zhou, M.-M. (deposition date: 2001-08-17, release date: 2002-08-17, Last modification date: 2011-07-13)
Primary citation
Mujtaba, S.,He, Y.,Zeng, L.,Yan, S.,Plotnikova, O.,Sachchidanand,Sanchez, R.,Zeleznik-Le, N.J.,Ronai, Z.,Zhou, M.M.
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13:251-263, 2004
PubMed: 14759370 (PDB entries with the same primary citation)
DOI: 10.1016/S1097-2765(03)00528-8
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers517.2%28.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload