4RXZ
Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide
Summary for 4RXZ
Entry DOI | 10.2210/pdb4rxz/pdb |
Related | 2Z5T 3DAC 3EQY |
Descriptor | Protein Mdm4, 12-MER PEPTIDE INHIBITOR (3 entities in total) |
Functional Keywords | mdm4, mdmx-peptide inhibitor complex, oncoprotein, metal-binding, pmi, inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: O15151 |
Total number of polymer chains | 4 |
Total formula weight | 22509.94 |
Authors | Pazgier, M.,Gohain, N.,Tolbert, W.D. (deposition date: 2014-12-12, release date: 2015-07-22, Last modification date: 2023-12-06) |
Primary citation | Chen, X.,Gohain, N.,Zhan, C.,Lu, W.Y.,Pazgier, M.,Lu, W. Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene, 35:1919-1925, 2016 Cited by PubMed: 26148237DOI: 10.1038/onc.2015.255 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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