4BUZ

SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD

Summary for 4BUZ

Entry DOI	10.2210/pdb4buz/pdb
Related	4BV2 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH
Descriptor	NAD-DEPENDENT PROTEIN DEACETYLASE, CELLULAR TUMOR ANTIGEN P53, (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, ... (8 entities in total)
Functional Keywords	hydrolase, nad-dependent deacetylase, sirtuin, inhibitor complex, ex-527, running reaction
Biological source	THERMOTOGA MARITIMA More
Cellular location	Cytoplasm (By similarity): Q9WYW0 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains	2
Total formula weight	30344.21
Authors	Weyand, M.,Lakshminarasimhan, M.,Gertz, M.,Steegborn, C. (deposition date: 2013-06-24, release date: 2013-07-17, Last modification date: 2023-12-20)
Primary citation	Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013 Cited by PubMed: 23840057 DOI: 10.1073/PNAS.1303628110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation