4BUZ
SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE OCZ A 1247 |
| Chain | Residue |
| A | PRO31 |
| A | VAL160 |
| A | HOH2020 |
| A | HOH2021 |
| P | ALY382 |
| A | PHE33 |
| A | PHE48 |
| A | MET71 |
| A | GLN98 |
| A | ASN99 |
| A | ILE100 |
| A | ASP101 |
| A | ILE159 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD A 1248 |
| Chain | Residue |
| A | GLY21 |
| A | ALA22 |
| A | GLY23 |
| A | THR26 |
| A | PRO27 |
| A | ILE30 |
| A | PRO31 |
| A | ASP32 |
| A | PHE33 |
| A | GLN98 |
| A | ASN99 |
| A | ILE100 |
| A | ASP101 |
| A | HIS116 |
| A | GLY188 |
| A | SER189 |
| A | SER190 |
| A | ASN214 |
| A | LEU215 |
| A | MET230 |
| A | ASP231 |
| A | VAL232 |
| A | HOH2020 |
| A | HOH2021 |
| A | HOH2161 |
| A | HOH2196 |
| A | HOH2197 |
| P | ALY382 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE OAD A 1249 |
| Chain | Residue |
| A | GLY21 |
| A | ALA22 |
| A | GLY23 |
| A | THR26 |
| A | PRO27 |
| A | ASP32 |
| A | PHE33 |
| A | PHE48 |
| A | HIS116 |
| A | VAL160 |
| A | PHE162 |
| A | GLY188 |
| A | SER189 |
| A | SER190 |
| A | VAL193 |
| A | ASN214 |
| A | LEU215 |
| A | MET230 |
| A | ASP231 |
| A | VAL232 |
| A | HOH2020 |
| A | HOH2161 |
| A | HOH2196 |
| A | HOH2197 |
| P | ALY382 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1250 |
| Chain | Residue |
| A | CYS124 |
| A | CYS127 |
| A | CYS148 |
| A | CYS151 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1251 |
| Chain | Residue |
| A | TYR123 |
| A | LYS130 |
| A | HOH2107 |
| A | HOH2114 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4F","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15780941","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YC5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15780941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18786399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19801667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21080423","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JR3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PDH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
