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3GJR	Caspase-3 Binds Diverse P4 Residues in Peptides Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, GLYCEROL, ... Authors: Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T. Deposit date: 2009-03-09 Release date: 2009-03-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009
3GJQ	Caspase-3 Binds Diverse P4 Residues in Peptides Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, peptide inhibitor Authors: Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T. Deposit date: 2009-03-09 Release date: 2009-03-24 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009
3GJT	Caspase-3 Binds Diverse P4 Residues in Peptides Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, peptide inhibitor Authors: Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T. Deposit date: 2009-03-09 Release date: 2009-03-24 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009
3R6L	Caspase-2 T380A bound with Ac-VDVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)VDVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-21 Release date: 2011-07-27 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R7B	Caspase-2 bound to one copy of Ac-DVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-22 Release date: 2011-07-27 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3QNW	Caspase-6 in complex with Z-VAD-FMK inhibitor Descriptor: Caspase-6, Z-VAD-FMK Authors: Mueller, I, Lamers, M, Ritchie, A, Park, H, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. Deposit date: 2011-02-09 Release date: 2011-09-21 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation. Bioorg.Med.Chem.Lett., 21, 2011
4LSZ	Caspase-7 in Complex with DARPin D7.18 Descriptor: Caspase-7 subunit p10, Caspase-7 subunit p20, DARPin D7.18 Authors: Fluetsch, A, Lukarska, M, Gruetter, M.G. Deposit date: 2013-07-23 Release date: 2014-07-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise. Biochem.J., 461, 2014
3R7N	Caspase-2 bound with two copies of Ac-DVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-22 Release date: 2011-07-27 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
4JJ8	Caspase-3 specific unnatural amino acid peptides Descriptor: Caspase Inhibitor, Caspase-7 Authors: Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W. Deposit date: 2013-03-07 Release date: 2013-06-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.937 Å) Cite: Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. Acs Chem.Biol., 8, 2013
4JJE	Caspase-3 specific unnatural amino acid peptides Descriptor: Caspase inhibitor, Caspase-3 Authors: Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W. Deposit date: 2013-03-07 Release date: 2013-06-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.481 Å) Cite: Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. Acs Chem.Biol., 8, 2013
4JJ7	Caspase-3 specific unnatural amino acid-based peptides Descriptor: Caspase inhibitor, Caspase-8, DITHIANE DIOL Authors: Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W. Deposit date: 2013-03-07 Release date: 2013-06-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.178 Å) Cite: Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. Acs Chem.Biol., 8, 2013
8SPB	Caspase-4/Pro-IL-18 complex Descriptor: Caspase-4 subunit p10, Caspase-4 subunit p20, Interleukin-18 Authors: Pascal, D, Dong, Y, Wu, H, Jon, K. Deposit date: 2023-05-02 Release date: 2023-11-22 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into cytokine cleavage by inflammatory caspase-4. Nature, 624, 2023
4ZVR	Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to DEVD inhibitor. Descriptor: Caspase-7, Peptide ACE-ASP-GLU-VAL-ASJ Authors: Hill, M.E, MacPherson, D.J, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVP	Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to DEVD inhibitor. Descriptor: Caspase-7, Peptide ACE-ASP-GLU-VAL-ASA Authors: Hill, M.E, MacPherson, D.J, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVT	Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to VEID inhibitor. Descriptor: Caspase-7, VEID inhibitor Authors: Hardy, J.A, MacPherson, D.J, Hill, M.E. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVS	Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to DEVD inhibitor. Descriptor: Caspase-7, DEVD inhibitor Authors: MacPherson, D.J, Hill, M.E, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
6X8L	Caspase-7 in complex with elongated ketomethylene inhibitor Descriptor: Caspase-7, ketomethylene inhibitor Authors: Solania, A, Xu, J.H, Wolan, D.W. Deposit date: 2020-06-01 Release date: 2021-06-02 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Caspase-7 in complex with elongated ketomethylene inhibitor To Be Published
6X8K	Caspase-3 in complex with elongated ketomethylene inhibitor Descriptor: Caspase-3, ketomethylene inhibitor Authors: Solania, A, Xu, J.H, Wolan, D.W. Deposit date: 2020-06-01 Release date: 2021-06-02 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Caspase-3 in complex with elongated ketomethylene inhibitor To Be Published
2XYG	Caspase-3:CAS329306 Descriptor: CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide Authors: Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. Deposit date: 2010-11-17 Release date: 2011-08-17 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.54 Å) Cite: In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011
2XYP	Caspase-3:CAS26049945 Descriptor: CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE Authors: Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. Deposit date: 2010-11-18 Release date: 2011-08-17 Last modified: 2025-10-01 Method: X-RAY DIFFRACTION (1.86 Å) Cite: In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011
4ZVU	Caspase-7 wild-type bound to the caspase-6 cognate tetrapeptide inhibitor Ac-VEID-cho Descriptor: Caspase-7, Tetrapeptide Inhibitor Ac-VEID-CHO Authors: Hardy, J.A, MacPherson, D.J, Hill, M.E. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.601 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVO	Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to VEID inhibitor. Descriptor: Caspase-7, Peptide ACE-VAL-GLU-ILE-ASJ Authors: Hill, M.E, MacPherson, D.J, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
4ZVQ	Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to VEID inhibitor. Descriptor: Caspase-7, Peptide ACE-VAL-GLU-ILE-ASA Authors: Hill, M.E, MacPherson, D.J, Hardy, J.A. Deposit date: 2015-05-18 Release date: 2016-04-20 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11, 2016
6KMV	caspase-11 C254A P22/P10 in complex with mouse GSDMD-C domain Descriptor: Caspase-4, Gasdermin-D Authors: Ding, J, Sun, Q. Deposit date: 2019-08-01 Release date: 2020-03-11 Last modified: 2025-03-12 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
6KN0	caspase-1 P20/P10 C285A in complex with human GSDMD-C domain Descriptor: Caspase-1, Gasdermin-D Authors: Ding, J, Sun, Q. Deposit date: 2019-08-02 Release date: 2020-03-11 Last modified: 2025-03-12 Method: X-RAY DIFFRACTION (2.793 Å) Cite: Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020

 

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