3PCX
Caspase-3 E246A, K242A Double Mutant
Summary for 3PCX
Entry DOI | 10.2210/pdb3pcx/pdb |
Related | 3PD0 3PD1 |
Related PRD ID | PRD_000238 |
Descriptor | Caspase-3, Inhibitor Ac-DEVD-CMK (3 entities in total) |
Functional Keywords | salt bridge, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P42574 |
Total number of polymer chains | 2 |
Total formula weight | 29089.48 |
Authors | Walters, J.,Swartz, P.,Mattos, C.,Clark, A.C. (deposition date: 2010-10-22, release date: 2011-02-23, Last modification date: 2012-12-12) |
Primary citation | Walters, J.,Swartz, P.,Mattos, C.,Clark, A.C. Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch.Biochem.Biophys., 508:31-38, 2011 Cited by PubMed: 21266160DOI: 10.1016/j.abb.2011.01.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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