3RJM

CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c

Summary for 3RJM

Entry DOI	10.2210/pdb3rjm/pdb
Related PRD ID	PRD_000786
Descriptor	Caspase-2, Peptide inhibitor (ACE)VDV(3PX)D-CHO, ... (4 entities in total)
Functional Keywords	caspase-2, p12, p19, caspase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	65885.56
Authors	Abendroth, J.,Lorimer, D.,Stewart, L.,Maillard, M.,Kiselyov, A.S. (deposition date: 2011-04-15, release date: 2011-09-21, Last modification date: 2023-12-06)
Primary citation	Maillard, M.C.,Brookfield, F.A.,Courtney, S.M.,Eustache, F.M.,Gemkow, M.J.,Handel, R.K.,Johnson, L.C.,Johnson, P.D.,Kerry, M.A.,Krieger, F.,Meniconi, M.,Munoz-Sanjuan, I.,Palfrey, J.J.,Park, H.,Schaertl, S.,Taylor, M.G.,Weddell, D.,Dominguez, C. Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg.Med.Chem., 19:5833-5851, 2011 Cited by PubMed: 21903398 DOI: 10.1016/j.bmc.2011.08.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation