3RJM

CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Caspase-2	polymer	169	18992.5	2	UniProt (P42575) Pfam (PF00656)	Homo sapiens (human)	CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12
2	B, D (B, D)	Caspase-2	polymer	117	13336.5	2	UniProt (P42575) Pfam (PF00656)	Homo sapiens (human)	CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12
3	E, F (E, F)	Peptide inhibitor (ACE)VDV(3PX)D-CHO	polymer	6	613.7	2	BIRD (PRD_000786)
4	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	220	Chemie (HOH)

Sequence modifications

A, C: 2 - 168 (UniProt: P42575)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag

B, D: 201 - 305 (UniProt: P42575)

PDB	External Database	Details
Met 200	-	expression tag
Ala 306	-	expression tag
Ala 307	-	expression tag
Ala 308	-	expression tag
Leu 309	-	expression tag
Glu 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	65885.6
All*	Total formula weight	65885.6

*Water molecules are not included.