2XYP

Caspase-3:CAS26049945

Summary for 2XYP

• Entry DOI: 10.2210/pdb2xyp/pdb
• Related: 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2J30 2J31 2J32 2J33 2XYG 2XYH
• Descriptor: CASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE, ... (4 entities in total)
• Functional Keywords: hydrolase, in silico screening, docking, apoptosis
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P42574 P42574
• Total number of polymer chains: 2
• Total formula weight: 27873.27

Authors

Ganesan, R.,Jelakovic, S.,Grutter, M.G.,Mittl, P.R. (deposition date: 2010-11-18, release date: 2011-08-17, Last modification date: 2017-06-28)

• Primary citation: Ganesan, R.,Jelakovic, S.,Mittl, P.R.,Caflisch, A.,Grutter, M.G.; In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety.; Acta Crystallogr.,Sect.F, 67:842-, 2011; PubMed: 21821879; DOI: 10.1107/S1744309111018604

Experimental method

X-RAY DIFFRACTION (1.86 Å)