2CNO
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
Summary for 2CNO
Entry DOI | 10.2210/pdb2cno/pdb |
Related | 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN |
Related PRD ID | PRD_000670 |
Descriptor | Caspase-3, Aza-peptide epoxide, ... (4 entities in total) |
Functional Keywords | thiol protease, phosphorylation, cysteine-protease, protease-inhibitor complex, epoxides, apoptosis, hydrolase, aza-peptide, epoxysuccinyl, ice, yama, cpp32, clan cd, aza-asp, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P42574 2CNO |
Total number of polymer chains | 3 |
Total formula weight | 29312.73 |
Authors | Ganesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Powers, J.C.,Grutter, M.G. (deposition date: 2006-05-22, release date: 2007-05-22, Last modification date: 2024-07-17) |
Primary citation | Ganesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Powers, J.C.,Grutter, M.G. Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors Biochemistry, 45:9059-, 2006 Cited by PubMed: 16866351DOI: 10.1021/BI060364P PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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