2CNO

Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.

Summary for 2CNO

Entry DOI	10.2210/pdb2cno/pdb
Related	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN
Related PRD ID	PRD_000670
Descriptor	Caspase-3, Aza-peptide epoxide, ... (4 entities in total)
Functional Keywords	thiol protease, phosphorylation, cysteine-protease, protease-inhibitor complex, epoxides, apoptosis, hydrolase, aza-peptide, epoxysuccinyl, ice, yama, cpp32, clan cd, aza-asp, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P42574 2CNO
Total number of polymer chains	3
Total formula weight	29312.73
Authors	Ganesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Powers, J.C.,Grutter, M.G. (deposition date: 2006-05-22, release date: 2007-05-22, Last modification date: 2023-08-23)
Primary citation	Ganesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Powers, J.C.,Grutter, M.G. Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors Biochemistry, 45:9059-, 2006 Cited by PubMed: 16866351 DOI: 10.1021/BI060364P PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation