8SPB

Caspase-4/Pro-IL-18 complex

Summary for 8SPB

Entry DOI	10.2210/pdb8spb/pdb
EMDB information	40678
Descriptor	Caspase-4 subunit p20, Caspase-4 subunit p10, Interleukin-18 (3 entities in total)
Functional Keywords	innate immune, complex, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	111948.78
Authors	Pascal, D.,Dong, Y.,Wu, H.,Jon, K. (deposition date: 2023-05-02, release date: 2023-11-22, Last modification date: 2023-12-27)
Primary citation	Devant, P.,Dong, Y.,Mintseris, J.,Ma, W.,Gygi, S.P.,Wu, H.,Kagan, J.C. Structural insights into cytokine cleavage by inflammatory caspase-4. Nature, 624:451-459, 2023 Cited by PubMed: 37993712 DOI: 10.1038/s41586-023-06751-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation