8SPB

Caspase-4/Pro-IL-18 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, a)	Caspase-4 subunit p20	polymer	207	23353.4	2	UniProt (P49662) Pfam (PF00656)	Homo sapiens (human)
2	B, E (B, b)	Caspase-4 subunit p10	polymer	92	10770.4	2	UniProt (P49662) Pfam (PF00656)	Homo sapiens (human)
3	C, F (C, c)	Interleukin-18	polymer	188	21850.6	2	UniProt (Q14116) Pfam (PF00340)	Homo sapiens (human)

Sequence modifications

A, a: 94 - 270 (UniProt: P49662)

PDB	External Database	Details
Met 64	-	expression tag
Gly 65	-	expression tag
Ser 66	-	expression tag
Ser 67	-	expression tag
His 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
Ser 74	-	expression tag
Ser 75	-	expression tag
Gly 76	-	expression tag
Leu 77	-	expression tag
Val 78	-	expression tag
Pro 79	-	expression tag
Arg 80	-	expression tag
Gly 81	-	expression tag
Ser 82	-	expression tag
His 83	-	expression tag
Met 84	-	expression tag
Glu 85	-	expression tag
Asn 86	-	expression tag
Leu 87	-	expression tag
Tyr 88	-	expression tag
Phe 89	-	expression tag
Gln 90	-	expression tag
Gly 91	-	expression tag
Gly 92	-	expression tag
Ser 93	-	expression tag
Ala 258	Cys 258	conflict

B, b: 290 - 377 (UniProt: P49662)

PDB	External Database	Details
Met 286	-	initiating methionine
Gly 287	-	expression tag
Ala 288	-	expression tag
Ser 289	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	111948.8
All*	Total formula weight	111948.8

*Water molecules are not included.