8SPB

Caspase-4/Pro-IL-18 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004197	molecular_function	cysteine-type endopeptidase activity
a	0006508	biological_process	proteolysis
a	0008234	molecular_function	cysteine-type peptidase activity
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
b	0004197	molecular_function	cysteine-type endopeptidase activity
b	0006508	biological_process	proteolysis
b	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
c	0001525	biological_process	angiogenesis
c	0001819	biological_process	positive regulation of cytokine production
c	0005125	molecular_function	cytokine activity
c	0005515	molecular_function	protein binding
c	0005576	cellular_component	extracellular region
c	0005615	cellular_component	extracellular space
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006954	biological_process	inflammatory response
c	0006955	biological_process	immune response
c	0007267	biological_process	cell-cell signaling
c	0008283	biological_process	cell population proliferation
c	0010628	biological_process	positive regulation of gene expression
c	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
c	0030101	biological_process	natural killer cell activation
c	0030155	biological_process	regulation of cell adhesion
c	0030431	biological_process	sleep
c	0032722	biological_process	positive regulation of chemokine production
c	0032725	biological_process	positive regulation of granulocyte macrophage colony-stimulating factor production
c	0032729	biological_process	positive regulation of type II interferon production
c	0032736	biological_process	positive regulation of interleukin-13 production
c	0032740	biological_process	positive regulation of interleukin-17 production
c	0032819	biological_process	positive regulation of natural killer cell proliferation
c	0034105	biological_process	positive regulation of tissue remodeling
c	0035655	biological_process	interleukin-18-mediated signaling pathway
c	0042088	biological_process	T-helper 1 type immune response
c	0042092	biological_process	type 2 immune response
c	0042104	biological_process	positive regulation of activated T cell proliferation
c	0042119	biological_process	neutrophil activation
c	0042267	biological_process	natural killer cell mediated cytotoxicity
c	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
c	0042632	biological_process	cholesterol homeostasis
c	0045515	molecular_function	interleukin-18 receptor binding
c	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
c	0045662	biological_process	negative regulation of myoblast differentiation
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0048018	molecular_function	receptor ligand activity
c	0048661	biological_process	positive regulation of smooth muscle cell proliferation
c	0050729	biological_process	positive regulation of inflammatory response
c	0050830	biological_process	defense response to Gram-positive bacterium
c	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
c	0051142	biological_process	positive regulation of NK T cell proliferation
c	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
c	0061436	biological_process	establishment of skin barrier
c	0070328	biological_process	triglyceride homeostasis
c	0120162	biological_process	positive regulation of cold-induced thermogenesis
c	0150078	biological_process	positive regulation of neuroinflammatory response
c	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
c	2000556	biological_process	positive regulation of T-helper 1 cell cytokine production
C	0001525	biological_process	angiogenesis
C	0001819	biological_process	positive regulation of cytokine production
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007267	biological_process	cell-cell signaling
C	0008283	biological_process	cell population proliferation
C	0010628	biological_process	positive regulation of gene expression
C	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
C	0030101	biological_process	natural killer cell activation
C	0030155	biological_process	regulation of cell adhesion
C	0030431	biological_process	sleep
C	0032722	biological_process	positive regulation of chemokine production
C	0032725	biological_process	positive regulation of granulocyte macrophage colony-stimulating factor production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032736	biological_process	positive regulation of interleukin-13 production
C	0032740	biological_process	positive regulation of interleukin-17 production
C	0032819	biological_process	positive regulation of natural killer cell proliferation
C	0034105	biological_process	positive regulation of tissue remodeling
C	0035655	biological_process	interleukin-18-mediated signaling pathway
C	0042088	biological_process	T-helper 1 type immune response
C	0042092	biological_process	type 2 immune response
C	0042104	biological_process	positive regulation of activated T cell proliferation
C	0042119	biological_process	neutrophil activation
C	0042267	biological_process	natural killer cell mediated cytotoxicity
C	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
C	0042632	biological_process	cholesterol homeostasis
C	0045515	molecular_function	interleukin-18 receptor binding
C	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
C	0045662	biological_process	negative regulation of myoblast differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048018	molecular_function	receptor ligand activity
C	0048661	biological_process	positive regulation of smooth muscle cell proliferation
C	0050729	biological_process	positive regulation of inflammatory response
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051142	biological_process	positive regulation of NK T cell proliferation
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0061436	biological_process	establishment of skin barrier
C	0070328	biological_process	triglyceride homeostasis
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0150078	biological_process	positive regulation of neuroinflammatory response
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	2000556	biological_process	positive regulation of T-helper 1 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HkssdStfLvLMSHG

Chain	Residue	Details
A	HIS197-GLY211

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:36624349

Chain	Residue	Details
B	ARG314
b	ARG314

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7743998

Chain	Residue	Details
A	ALA258
a	ALA258

---