4ZVU

Caspase-7 wild-type bound to the caspase-6 cognate tetrapeptide inhibitor Ac-VEID-cho

Summary for 4ZVU

• Entry DOI: 10.2210/pdb4zvu/pdb
• Related: 1F1J 3EDR 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT
• Related PRD ID: PRD_000929
• Descriptor: Caspase-7, Tetrapeptide Inhibitor Ac-VEID-CHO, ... (4 entities in total)
• Functional Keywords: directed evolution, protease, peptide inhibitor, designed active site specificity, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 71799.12

Authors

Hardy, J.A.,MacPherson, D.J.,Hill, M.E. (deposition date: 2015-05-18, release date: 2016-04-20, Last modification date: 2023-11-15)

• Primary citation: Hill, M.E.,MacPherson, D.J.,Wu, P.,Julien, O.,Wells, J.A.,Hardy, J.A.; Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.; Acs Chem.Biol., 11:1603-1612, 2016; PubMed: 27032039; DOI: 10.1021/acschembio.5b00971

Experimental method

X-RAY DIFFRACTION (2.601 Å)