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8R3L	Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 3' vRNA end (51-mer vRNA loop), Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-11-09 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8X1V	NMR structure of a bimolecular parallel G-quadruplex formed by AAGGG repeats from pathogenic RFC1 gene Descriptor: DNA (5'-D(*AP*AP*GP*GP*GP*AP*AP*GP*GP*GP*AP*A)-3') Authors: Wang, Y, Guo, P, Han, D. Deposit date: 2023-11-08 Release date: 2024-01-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural investigation of pathogenic RFC1 AAGGG pentanucleotide repeats reveals a role of G-quadruplex in dysregulated gene expression in CANVAS. Nucleic Acids Res., 52, 2024
8UX1	Cryo-EM structure of Ran bound to RCC1 and the nucleosome core particle Descriptor: 153-bp Widom 601 DNA forward strand, 153-bp Widom 601 DNA reverse strand, GTP-binding nuclear protein Ran, ... Authors: Huang, S.K, Rubinstein, J.L, Kay, L.E. Deposit date: 2023-11-08 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Cryo-EM structure of Ran bound to RCC1 and the nucleosome core particle To Be Published
8X1H	Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 Descriptor: GLYCEROL, Nucleoprotein Authors: Kumari, S, Gupta, G.D. Deposit date: 2023-11-07 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 To Be Published
8X15	Structure of nucleosome-bound SRCAP-C in the apo state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of nucleosome-bound SRCAP-C in the apo state To Be Published
8UW3	Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state Descriptor: Complementary DNA, LINE-1 retrotransposable element ORF2 protein, THYMIDINE-5'-TRIPHOSPHATE, ... Authors: Thawani, A, Florez Ariza, A.J, Collins, K, Nogales, E. Deposit date: 2023-11-06 Release date: 2023-12-20 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Template and target-site recognition by human LINE-1 in retrotransposition. Nature, 626, 2024
8X19	Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state To Be Published
8X1C	Structure of nucleosome-bound SRCAP-C in the ADP-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of nucleosome-bound SRCAP-C in the ADP-bound state To Be Published
8UV0	Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2 Descriptor: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2 Authors: Deller, M.C, Epling, L.B. Deposit date: 2023-11-02 Release date: 2024-02-14 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2. J.Med.Chem., 67, 2024
8R1L	Structure of avian H5N1 influenza A polymerase in complex with human ANP32B. Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. Deposit date: 2023-11-02 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B. To Be Published
8R1J	Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B. Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. Deposit date: 2023-11-02 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B. To Be Published
8R1F	Monomeric E6AP-E6-p53 ternary complex Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... Authors: Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. Deposit date: 2023-11-01 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Monomeric E6AP-E6-p53 ternary complex To Be Published
8R1G	Dimeric ternary structure of E6AP-E6-p53 Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... Authors: Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. Deposit date: 2023-11-01 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.99 Å) Cite: Monomeric E6AP-E6-p53 ternary complex To Be Published
8UU9	Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-D) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UU8	Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-C) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UU4	Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HPF (structure I-A) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UUA	Cryo-EM structure of the Listeria innocua 50S ribosomal subunit in complex with HflXr (structure III) Descriptor: 23S Ribosomal RNA, 5S Ribosomal RNA, GTPase HflX, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UU6	Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome in complex with p/E-tRNA (structure II-A) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UU7	Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HflXr, HPF, and E-site tRNA (structure II-B) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8R08	Cryo-EM structure of the cross-exon pre-B+AMPPNP complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-31 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (6.1 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch Nature, 2024
8R09	Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-31 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch Nature, 2024
8R0A	Cryo-EM structure of the cross-exon pre-B+5'ss complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-31 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch Nature, 2024
8R0B	Cryo-EM structure of the cross-exon pre-B+ATP complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2023-10-31 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch Nature, 2024
8UU5	Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UTA	yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N Descriptor: Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, MAGNESIUM ION, ... Authors: Krochmal, D, Lewicka, A, Piccirilli, J.A. Deposit date: 2023-10-30 Release date: 2024-04-10 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov, 10, 2024

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