8R3L

Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A

Summary for 8R3L

• Entry DOI: 10.2210/pdb8r3l/pdb
• EMDB information: 18872
• Descriptor: Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (5 entities in total)
• Functional Keywords: viral polymerase, viral protein
• Biological source: Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)); More
• Total number of polymer chains: 6
• Total formula weight: 296738.89

Authors

Arragain, B.,Cusack, S. (deposition date: 2023-11-09, release date: 2024-02-21)

• Primary citation: Krischuns, T.,Arragain, B.,Isel, C.,Paisant, S.,Budt, M.,Wolff, T.,Cusack, S.,Naffakh, N.; The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.; Nat Commun, 15:1064-1064, 2024; PubMed: 38316757; DOI: 10.1038/s41467-024-45205-2

Experimental method

ELECTRON MICROSCOPY (3.25 Å)