6AVR
 
 | | Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609 | | Descriptor: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | | Authors: | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | | Deposit date: | 2017-09-04 | | Release date: | 2017-11-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (35 Å) | | Cite: | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
|
|
6AVQ
 | | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance | | Descriptor: | Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ... | | Authors: | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | | Deposit date: | 2017-09-04 | | Release date: | 2017-11-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (35 Å) | | Cite: | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
|
|
6AVU
 | | Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609 | | Descriptor: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | | Authors: | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | | Deposit date: | 2017-09-04 | | Release date: | 2017-11-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (35 Å) | | Cite: | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
|
|
5NEU
 | |
5NER
 | |
5NET
 | |
5NEM
 | |
5FFO
 | | Integrin alpha V beta 6 in complex with pro-TGF-beta | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Dong, X, Zhao, B, Springer, T.A. | | Deposit date: | 2015-12-18 | | Release date: | 2017-01-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
|
|
5FFG
 | | Crystal structure of integrin alpha V beta 6 head | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Dong, X, Springer, T.A. | | Deposit date: | 2015-12-18 | | Release date: | 2017-01-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
|
|
5ES4
 | | RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Sen, M, Springer, T.A. | | Deposit date: | 2015-11-16 | | Release date: | 2016-03-02 | | Last modified: | 2022-03-23 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5E6R
 | | Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-L, ... | | Authors: | Sen, M, Springer, T.A. | | Deposit date: | 2015-10-10 | | Release date: | 2016-03-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.901 Å) | | Cite: | Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5E6U
 | | Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sen, M, Springer, T.A. | | Deposit date: | 2015-10-10 | | Release date: | 2016-04-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5E6S
 | | Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-L, ... | | Authors: | Springer, T.A, Sen, M. | | Deposit date: | 2015-10-10 | | Release date: | 2016-03-02 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
4UM9
 | | Crystal structure of alpha V beta 6 with peptide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Dong, X, Springer, T.A. | | Deposit date: | 2014-05-15 | | Release date: | 2014-11-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
|
|
4UM8
 | | Crystal structure of alpha V beta 6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ... | | Authors: | Dong, X, Springer, T.A. | | Deposit date: | 2014-05-15 | | Release date: | 2014-11-12 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.852 Å) | | Cite: | Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
|
|
4O02
 | | AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment. | | Descriptor: | 17E6 heavy chain, 17E6 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Mahalingam, B, van Agthoven, J, Xiong, J, Arnaout, M.A. | | Deposit date: | 2013-12-13 | | Release date: | 2014-04-02 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.605 Å) | | Cite: | Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex.
J.Biol.Chem., 289, 2014
|
|
4NEH
 | | An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Sen, M, Yuki, K, Springer, T.A. | | Deposit date: | 2013-10-29 | | Release date: | 2014-01-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.7505 Å) | | Cite: | An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
J.Cell Biol., 203, 2013
|
|
4NEN
 | | An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sen, M, Yuki, K, Springer, T.A. | | Deposit date: | 2013-10-29 | | Release date: | 2014-01-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.9012 Å) | | Cite: | An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
J.Cell Biol., 203, 2013
|
|
4CAK
 | | Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-IIb, ... | | Authors: | Choi, W.S, Rice, W.J, Stokes, D.L, Coller, B.S. | | Deposit date: | 2013-10-08 | | Release date: | 2013-10-30 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (20.5 Å) | | Cite: | Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding.
Blood, 122, 2013
|
|
4MMX
 | | Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | | Authors: | van Agthoven, J, Xiong, J, Arnaout, M.A. | | Deposit date: | 2013-09-09 | | Release date: | 2014-03-26 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.32 Å) | | Cite: | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
|
|
4MMY
 | | Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | | Authors: | van Agthoven, J, Xiong, J, Arnaout, M.A. | | Deposit date: | 2013-09-09 | | Release date: | 2014-03-26 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.183 Å) | | Cite: | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
|
|
4MMZ
 | | Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | | Authors: | van Agthoven, J, Xiong, J, Arnaout, M.A. | | Deposit date: | 2013-09-09 | | Release date: | 2014-03-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
|
|
4IRZ
 | | Crystal structure of A4b7 headpiece complexed with Fab Natalizumab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Yu, Y, Schurpf, T, Springer, T.A. | | Deposit date: | 2013-01-15 | | Release date: | 2013-09-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | How natalizumab binds and antagonizes alpha 4 integrins.
J.Biol.Chem., 288, 2013
|
|
4G1E
 | | Crystal structure of integrin alpha V beta 3 with coil-coiled tag. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Dong, X, Mi, L, Zhu, J, Wang, W, Luo, B, Springer, T.A. | | Deposit date: | 2012-07-10 | | Release date: | 2012-12-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | AlphaV Beta3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
|
|
4G1M
 | | Re-refinement of alpha V beta 3 structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Springer, T.A, Mi, L, Zhu, J. | | Deposit date: | 2012-07-10 | | Release date: | 2012-12-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
|
|
