PDB: 2407 件ウェブページステータス検索Chemie searchBIRD

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1M14	Tyrosine Kinase Domain from Epidermal Growth Factor Receptor 分子名称: Epidermal growth factor receptor 著者 Stamos, J, Sliwkowski, M.X, Eigenbrot, C. 登録日 2002-06-17 公開日 2002-09-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J.Biol.Chem., 277, 2002
1MP8	Crystal structure of Focal Adhesion Kinase (FAK) 分子名称: ADENOSINE-5'-DIPHOSPHATE, focal adhesion kinase 1 著者 Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C.G, Pavletich, N.P, Rodgers, J, Sang, B.-C, Scheibe, D.N, Swanson, R.V, Thompson, D.A. 登録日 2002-09-11 公開日 2003-09-16 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography Structure, 10, 2002
1M52	Crystal Structure of the c-Abl Kinase domain in complex with PD173955 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 著者 Nagar, B, Bornmann, W, Pellicena, P, Schindler, T, Veach, D, Miller, W.T, Clarkson, B, Kuriyan, J. 登録日 2002-07-08 公開日 2002-09-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571) Cancer Res., 62, 2002
1MQB	Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase 分子名称: Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C, Pavletich, N, Rogers, J, Sang, B.C, Scheibe, D.N, Swanson, R.V, Thompson, D.A. 登録日 2002-09-16 公開日 2003-09-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of the Cancer Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography Structure, 10, 2003
1OEC	FGFr2 kinase domain 分子名称: 4-ARYL-2-PHENYLAMINO PYRIMIDINE, FIBROBLAST GROWTH FACTOR RECEPTOR 2, SULFATE ION 著者 Ceska, T.A, Owens, R, Doyle, C, Hamlyn, P, Crabbe, T, Moffat, D, Davis, J, Martin, R, Perry, M.J. 登録日 2003-03-24 公開日 2004-10-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Crystal Structure of the Fgfr2 Tyrosine Kinase Domain in Complex with 4-Aryl-2-Phenylamino Pyrimidine Angiogenesis Inhibitors To be Published
1OPJ	Structural basis for the auto-inhibition of c-Abl tyrosine kinase 分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, MYRISTIC ACID, ... 著者 Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. 登録日 2003-03-06 公開日 2003-04-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1P4O	Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution. 分子名称: Insulin-like growth factor I receptor protein 著者 Munshi, S, Kornienko, M, Hall, D.L, Darke, P.L, Waxman, L, Kuo, L.C. 登録日 2003-04-23 公開日 2003-04-29 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution. Acta Crystallogr.,Sect.D, 59, 2003
1P14	Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase 分子名称: insulin receptor 著者 Li, S, Covino, N.D, Stein, E.G, Till, J.H, Hubbard, S.R. 登録日 2003-04-11 公開日 2003-07-22 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor J.Biol.Chem., 278, 2003
1PKG	Structure of a c-Kit Kinase Product Complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, c-kit protein 著者 Mol, C.D, Lim, K.B, Sridhar, V, Zou, H, Chien, E.Y.T, Sang, B.-C, Nowakowski, J, Kassel, D.B, Cronin, C.N, McRee, D.E. 登録日 2003-06-05 公開日 2003-08-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation. J.Biol.Chem., 278, 2003
1QPD	STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS 分子名称: LCK KINASE, STAUROSPORINE, SULFATE ION 著者 Zhu, X, Kim, J.L, Rose, P.E, Stover, D.R, Toledo, L.M, Zhao, H, Morgenstern, K.A. 登録日 1999-05-24 公開日 2000-05-24 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors. Structure Fold.Des., 7, 1999
1QPE	STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS 分子名称: 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, LCK KINASE, SULFATE ION 著者 Zhu, X, Morgenstern, K.A. 登録日 1999-05-24 公開日 2000-05-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors. Structure Fold.Des., 7, 1999
1QPJ	CRYSTAL STRUCTURE OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH STAUROSPORINE. 分子名称: LCK TYROSINE KINASE, STAUROSPORINE, SULFATE ION 著者 Zhu, X, Kim, J.L, Rose, P.E, Stover, D.R, Toledo, L.M. 登録日 1999-05-25 公開日 2000-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors. Structure Fold.Des., 7, 1999
1QPC	STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS 分子名称: 1,2-ETHANEDIOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... 著者 Zhu, X, Kim, J.L, Rose, P.E, Stover, D.R, Toledo, L.M, Zhao, H, Morgenstern, K.A. 登録日 1999-05-21 公開日 2000-05-24 最終更新日 2015-08-19 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors. Structure Fold.Des., 7, 1999
1R0P	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a 分子名称: Hepatocyte growth factor receptor, K-252A 著者 Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C. 登録日 2003-09-22 公開日 2003-10-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a Proc.Natl.Acad.Sci.USA, 100, 2003
1R1W	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET 分子名称: HEPATOCYTE GROWTH FACTOR RECEPTOR 著者 Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C. 登録日 2003-09-25 公開日 2003-10-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a Proc.Natl.Acad.Sci.USA, 100, 2003
1RJB	Crystal Structure of FLT3 分子名称: FL cytokine receptor 著者 Griffith, J, Black, J, Faerman, C, Swenson, L, Wynn, M, Lu, F, Lippke, J, Saxena, K. 登録日 2003-11-19 公開日 2004-02-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol.Cell, 13, 2004
1SNU	CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN 分子名称: STAUROSPORINE, Tyrosine-protein kinase ITK/TSK 著者 Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T. 登録日 2004-03-12 公開日 2004-07-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279, 2004
1SM2	Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain 分子名称: STAUROSPORINE, Tyrosine-protein kinase ITK/TSK 著者 Brown, K, Long, J.M, Vial, S.C.M, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T. 登録日 2004-03-08 公開日 2004-07-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279, 2004
1SNX	CRYSTAL STRUCTURE OF APO INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T. 登録日 2004-03-12 公開日 2004-07-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279, 2004
1T46	STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE 分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PHOSPHATE ION 著者 Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P. 登録日 2004-04-28 公開日 2004-06-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J.Biol.Chem., 279, 2004
1T45	STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE 分子名称: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 著者 Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P. 登録日 2004-04-28 公開日 2004-06-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J.Biol.Chem., 279, 2004
1U4D	Structure of the ACK1 Kinase Domain bound to Debromohymenialdisine 分子名称: Activated CDC42 kinase 1, CHLORIDE ION, DEBROMOHYMENIALDISINE 著者 Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. 登録日 2004-07-23 公開日 2004-08-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
1U46	Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 分子名称: Activated CDC42 kinase 1, CHLORIDE ION 著者 Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. 登録日 2004-07-23 公開日 2004-08-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
1U59	Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine 分子名称: STAUROSPORINE, Tyrosine-protein kinase ZAP-70 著者 Jin, L, Pluskey, S, Petrella, E.C, Cantin, S.M, Gorga, J.C, Rynkiewicz, M.J, Pandey, P, Strickler, J.E, Babine, R.E, Weaver, D.T, Seidl, K.J. 登録日 2004-07-27 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS J.Biol.Chem., 279, 2004
1U54	Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP 分子名称: Activated CDC42 kinase 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER 著者 Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. 登録日 2004-07-26 公開日 2004-08-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004

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