1P14
Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase
Summary for 1P14
| Entry DOI | 10.2210/pdb1p14/pdb |
| Related | 1IRK |
| Descriptor | insulin receptor (2 entities in total) |
| Functional Keywords | receptor, tyrosine kinase, catalysis, mutant, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Single-pass type I membrane protein: P06213 |
| Total number of polymer chains | 1 |
| Total formula weight | 34792.74 |
| Authors | Li, S.,Covino, N.D.,Stein, E.G.,Till, J.H.,Hubbard, S.R. (deposition date: 2003-04-11, release date: 2003-07-22, Last modification date: 2023-08-16) |
| Primary citation | Li, S.,Covino, N.D.,Stein, E.G.,Till, J.H.,Hubbard, S.R. Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor J.Biol.Chem., 278:26007-26014, 2003 Cited by PubMed: 12707268DOI: 10.1074/jbc.M302425200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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